Evidence map›Paper›PMID 38046324›Full record

ArticleACS omega2023

STAR: A Web Server for Assisting Directed Protein Evolution with Machine Learning.

Likun Yang, Xiaoli Liang, Na Zhang, Lu Lu

Abstract read
In one paragraph

Article in ACS omega, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Likun YangAsymchem Life Science (Tianjin) Co., Ltd, Tianjin 300457, P. R. China.ORCID https://orcid.org/0000-0001-6741-0766
Xiaoli LiangAsymchem Life Science (Tianjin) Co., Ltd, Tianjin 300457, P. R. China.
Na ZhangAsymchem Life Science (Tianjin) Co., Ltd, Tianjin 300457, P. R. China.
Lu LuAsymchem Life Science (Tianjin) Co., Ltd, Tianjin 300457, P. R. China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Protein engineering has made significant contributions to industries such as agriculture, food, and pharmaceuticals. In recent years, directed evolution combined with artificial intelligence has emerged as a cutting-edge R&D approach. However, the application of machine learning techniques can be challenging for those without relevant experience and coding skills. To address this issue, we have developed a web-based protein sequence recommendation system: STAR (Sequence recommendaTion via ARtificial intelligence). Our system utilizes Bayesian optimization as its backbone and includes a filtering step using a regression model to enhance the success rate of recommended sequences. Additionally, we have incorporated an in silico-directed evolution approach to expand the exploration of the protein space. The Web site can be accessed at https://www.FindProteinStar.com/.

Identifiers

PMID38046324
PMCPMC10688154

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.