Evidence map›Paper›PMID 38046284›Full record

Trial reportDrug design, development and therapy2023

Impact of Opioid-Free Anesthesia on Postoperative Quality of Recovery in Patients After Laparoscopic Cholecystectomy-A Randomized Controlled Trial.

Conghui Hao, Hai Xu, Jingjing Du, Tianyu Zhang, Xiaobao Zhang, Zhibin Zhao, Hengfei Luan

Registry-linked trialOpen access · goldAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Drug design, development and therapy, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07649746 (Evaluation of an Opioid-Free Approach in Sedation Method Selection in Endoscopy Units), which is not on this map. Cited by 33 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed, 2 pooled it
10.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07649746 nanot yet recruitingnot on this mapstarted 2026, after this paper: background citation

Evaluation of an Opioid-Free Approach in Sedation Method Selection in Endoscopy Units: A Prospective Randomized Observational Double-Blind Comparison of Dexmedetomidine (Opioid-Free) and Remifentanil-Dexmedetomidine (Opioid-Based) Combination

TypeinterventionalSponsorBakirkoy Dr. Sadi Konuk Research and Training HospitalRan2026 to 2028Enrolled80ConditionsSedation, Endoscopy, Colonoscopy, Endoscopic Retrograde Cholangiopancreatography (ERCP)ArmsDexmedetomidine, Remifentanil
3 · Its place in the literature

Who cites it

33 citing papers in PubMed, 2 syntheses or guidelines pooled it, 34 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Conghui HaoDepartment of Anesthesiology, Graduate Training Base of Lianyungang First People's Hospital of Jinzhou Medical University, Lianyungang, Jiangsu, People's Republic of China.
Hai XuDepartment of Anesthesiology, Graduate Training Base of Lianyungang First People's Hospital of Jinzhou Medical University, Lianyungang, Jiangsu, People's Republic of China.
Jingjing DuDepartment of Anesthesiology, Graduate Training Base of Lianyungang First People's Hospital of Jinzhou Medical University, Lianyungang, Jiangsu, People's Republic of China.
Tianyu ZhangDepartment of Anesthesiology, Graduate Training Base of Lianyungang First People's Hospital of Jinzhou Medical University, Lianyungang, Jiangsu, People's Republic of China.
Xiaobao ZhangDepartment of anesthesiology, The Affiliated Lianyungang Hospital of Xuzhou Medical University, The First People's Hospital of Lianyungang, Lianyungang, Jiangsu, People's Republic of China.
Zhibin ZhaoDepartment of anesthesiology, The Affiliated Lianyungang Hospital of Xuzhou Medical University, The First People's Hospital of Lianyungang, Lianyungang, Jiangsu, People's Republic of China.
Hengfei LuanDepartment of anesthesiology, The Affiliated Lianyungang Hospital of Xuzhou Medical University, The First People's Hospital of Lianyungang, Lianyungang, Jiangsu, People's Republic of China.
The First People’s Hospital of Lianyungang · CNJinzhou Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Purpose: Opioid analgesics may delay discharge and affect postoperative quality of recovery because of their significant adverse effects, such as hyperalgesia, postoperative nausea and vomiting (PONV), shivering and urine retention. We aimed to compare the quality of postoperative recovery (QoR) between patients undergoing laparoscopic cholecystectomy surgeries with opioid-free anesthesia (OFA) and those with opioid-based anesthesia (OA). Patients and Methods: 80 adult patients undergoing laparoscopic cholecystectomy were randomly allocated to an opioid-free anesthesia group (Group OFA) or an opioid-based anesthesia group (Group OA). The primary outcome was the quality of postoperative recovery using QoR-15 scale on postoperative day 1 (POD 1) and 2 (POD 2). The secondary outcomes included the incidence of opioid-related adverse symptoms, perioperative hemodynamic data, duration of post-anesthesia care unit (PACU) stay and duration of extubation, and the incidences of hypotension and bradycardia. Results: A statistically significant difference in total QoR-15 was observed between the two groups on POD 1 and POD 2 (91.00 (90.00, 92.00) vs 113.00 (108.25, 115.00), 106.00 (104.00, 112.00) vs 133.00 (130.00, 135.00), Conclusion: We concluded that the quality of recovery of patients receiving OFA was superior to those receiving OA after laparoscopic cholecystectomy.

Indexed as

AnesthesiaCholecystectomy, LaparoscopicHypotensionAdultAnalgesics, OpioidBradycardiaHumansPostoperative PainProspective StudiesAnalgesics, Opioidlaparoscopic cholecystectomyopioid-based anesthesiaopioid-free anesthesiapostoperative recovery

Identifiers

PMID38046284
PMCPMC10693280
OpenAlexW4389070956

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.