ArticlePlastic and reconstructive surgery. Global open2023
Lipedema Reduction Surgery Improves Pain, Mobility, Physical Function, and Quality of Life: Case Series Report.
Article in Plastic and reconstructive surgery. Global open, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Lipedema Diagnosis, Clinical Manifestations, and Therapeutics: A Systematic Review.International journal of dermatology · 2026Pooled it
- Lipedema: Progress, Challenges, and the Road Ahead.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2025Pooled it
- The Adipovascular Unit in Lipedema: A Framework for Regional Adipose Tissue Dysregulation.Cells · 2026Review
- The Utility of Ultrasound in the Management of Lipedema: Preoperative, Intraoperative, and Postoperative Applications.Aesthetic plastic surgery · 2026Review
- Cutaneous Sensory Alterations After Lower Limb Liposuction for Lipedema: A Comparative Study with Aesthetic Liposuction Patients.Aesthetic plastic surgery · 2026Article
- Macroscopic fat embolism after liposuction.Forensic science, medicine, and pathology · 2026Article
- Lipedema Reduction Surgery Outcomes and Comorbidities: A Retrospective Study.Plastic and reconstructive surgery. Global open · 2026Article
- Safety and Efficacy of Surgical Techniques in Treating Lipedema: Systematic Review.Aesthetic surgery journal. Open forum · 2026Review
- Quantifying Morphological Change in Stage III Lipedema: A 3D Imaging Study of Population Trends and Individual Treatment Courses.Journal of personalized medicine · 2025Article
- Lipedema and Hypermobility Spectrum Disorders Sharing Pathophysiology: A Cross-Sectional Observational Study.Journal of clinical medicine · 2025Article
- Article
- New Characterization of Lipedema Stages: Focus on Pain, Water, Fat and Skeletal Muscle.Life (Basel, Switzerland) · 2025Article
- Therapeutic Applications of Ketogenic Diets in Lipedema: A Narrative Review of Current Evidence.Current obesity reports · 2025Review
- An Advanced Pneumatic Compression Therapy System Improves Leg Volume and Fluid, Adipose Tissue Thickness, Symptoms, and Quality of Life and Reduces Risk of Lymphedema in Women with Lipedema.Life (Basel, Switzerland) · 2025Article
- Preoperative Routine Cold-water Immersion for Lipedema Reduction Surgery.Plastic and reconstructive surgery. Global open · 2024Article
- Health Implications of Lipedema: Analysis of Patient Questionnaires and Population-Based Matched Controls.Life (Basel, Switzerland) · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Lipedema is a chronic inflammatory subcutaneous adipose-rich connective tissue disease affecting millions of women worldwide. Disproportionate fat accumulation on the extremities characterized by heaviness, tenderness, and swelling can affect function, mobility, and quality of life. Treatments include conservative measures and lipedema reduction surgery (LRS). Here, we report lipedema comorbidities and surgical techniques, outcomes measures, and complications after LRS. Methods: This is a single outpatient clinic retrospective chart review case series of comorbidities and complications in 189 women with lipedema. Bioelectrical impedance analyses, knee kinematics, gait, physical examinations, Patient-Reported Outcomes Measurement Information System, and RAND Short Form-36 questionnaires collected before and after LRS were analyzed for 66 of the 189 women. Hemoglobin levels were measured by transdermal hemoglobin monitor (Masimo noninvasive hemoglobin monitoring; Irvine, Calif.). Results: Common comorbidities in 189 women were hypermobile joints (50.5%), spider/varicose veins (48.6/24.5%), arthritis (29.1%), and hypothyroidism (25.9%). The most common complication in 5.5% of these women after LRS was lightheadedness with a 2-g reduction or more in hemoglobin. After conservative measures and LRS in 66 women, significant improvements (P ≤ 0.0009) were found for: (1) knee flexion (10 degrees); (2) gait; (3) Patient-Reported Outcomes Measurement Information System T-score (16%); (4) mobility questions: gait velocity, rising from a chair, stair ascent; (5) RAND Short Form-36 scores: physical functioning, energy/fatigue, emotional well-being, social function, general health; (6) and Bioelectrical impedance analyses total and segmental body fat mass. Conclusion: LRS provided significant improvements to women with lipedema using direct physical measurements and validated outcome measures, comparable to those seen after total knee replacement.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.