Evidence map›Paper›PMID 38046198›Full record

ArticleMolecular therapy. Methods & clinical development2023

Fast HPLC-based affinity method to determine capsid titer and full/empty ratio of adeno-associated viral vectors.

Jakob Heckel, Andres Martinez, Carsten Elger, Markus Haindl, Michael Leiss, Raphael Ruppert, Chris Williams, Jürgen Hubbuch, Tobias Graf

Abstract read
In one paragraph

Article in Molecular therapy. Methods & clinical development, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Article
  6. Article
  7. Biomanufacturing in gene and cell therapy.Molecular therapy. Methods & clinical development · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Jakob HeckelPharma Technical Development Analytics, Roche Diagnostics GmbH, 82377 Penzberg, Germany.
Andres MartinezGene Therapy Technical Development, Roche Diagnostics GmbH, 82377 Penzberg, Germany.
Carsten ElgerGene Therapy Technical Development, Roche Diagnostics GmbH, 82377 Penzberg, Germany.
Markus HaindlGene Therapy Technical Development, Roche Diagnostics GmbH, 82377 Penzberg, Germany.
Michael LeissPharma Technical Development Analytics, Roche Diagnostics GmbH, 82377 Penzberg, Germany.
Raphael RuppertGene Therapy Technical Development, Roche Diagnostics GmbH, 82377 Penzberg, Germany.
Chris WilliamsGene Therapy Technical Development, Roche Diagnostics GmbH, 82377 Penzberg, Germany.
Jürgen HubbuchInstitute of Process Engineering in Life Sciences, Section IV: Biomolecular Separation Engineering, Karlsruhe Institute of Technology, 76131 Karlsruhe, Germany.
Tobias GrafPharma Technical Development Analytics, Roche Diagnostics GmbH, 82377 Penzberg, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Recombinant adeno-associated viruses (rAAVs) are promising gene delivery vectors in the emerging field of

Indexed as

AAVadeno-associatedaffinity chromatographycapsid titerfluorescencegene therapyhigh-throughputprocess development

Identifiers

PMID38046198
PMCPMC10690635

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.