Evidence map›Paper›PMID 38046009›Full record

ArticleClinical kidney journal2023

Long-term safety and efficacy of left atrial appendage occlusion in dialysis patients with atrial fibrillation: a multi-center, prospective, open label, observational study.

Simonetta Genovesi, Luca Porcu, Paola Rebora, Giorgio Slaviero, Gavino Casu, Silvio Bertoli, Flavio Airoldi, Monique Buskermolen, Maurizio Gallieni, Federico Pieruzzi and 12 more

Abstract read
In one paragraph

Article in Clinical kidney journal, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Left atrial appendage occlusion in patients with end-stage renal disease: an individual patient-level meta-analysis.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2025
    Pooled it
  3. Review
  4. Review
  5. Article
  6. SCAI/HRS Technical Review on Transcatheter Left Atrial Appendage Occlusion.Journal of the Society for Cardiovascular Angiography & Interventions · 2025
    Article
  7. 2025 SCAI/HRS Clinical Practice Guidelines on Transcatheter Left Atrial Appendage Occlusion.Journal of the Society for Cardiovascular Angiography & Interventions · 2025
    Article
  8. Article
  9. Review
  10. Review
  11. Treatment strategies of the thromboembolic risk in kidney failure patients with atrial fibrillation.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2024
    Review
  12. Incidence and predictors of 2-year mortality following percutaneous left atrial appendage occlusion in the EWOLUTION trial.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2024
    Article
  13. Article
  14. Practical guide on left atrial appendage closure for the non-implanting physician: an international consensus paper.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors.

Simonetta GenovesiSchool of Medicine and Surgery, University of Milano-Bicocca, Monza, Italy.ORCID https://orcid.org/0000-0002-4699-4149
Luca PorcuCancer Research UK Cambridge Institute, University of Cambridge, Cambridge, UK.
Paola ReboraSchool of Medicine and Surgery, University of Milano-Bicocca, Monza, Italy.ORCID https://orcid.org/0000-0003-0606-5852
Giorgio SlavieroNephrology Unit, IRCCS Ospedale San Raffaele, Milano, Italy.
Gavino CasuCardiology Unit, Azienda Ospedaliera Universitaria di Sassari, Sassari, Italy.
Silvio BertoliDialysis and Nephrology Unit-IRCCS-Multimedica, Sesto S.Giovanni, Italy.
Flavio AiroldiElectrophysiology Unit-IRCCS-Multimedica, Sesto S.Giovanni, Italy.
Monique BuskermolenNephrology and Dialysis Unit, ASST Fatebenefratelli Sacco, Milano, Italy.
Maurizio GallieniNephrology and Dialysis Unit, ASST Fatebenefratelli Sacco, Milano, Italy.ORCID https://orcid.org/0000-0002-2011-2160
Federico PieruzziSchool of Medicine and Surgery, University of Milano-Bicocca, Monza, Italy.
Giovanni RovarisInterventional Electrophysiology Unit, San Gerardo Hospital, Monza, Italy.
Alberto MontoliNephrology Unit, Niguarda Hospital, Milano, Italy.
Emanuela PiccalugaInterventional Cardiology Unit, Niguarda Hospital, Milano, Italy.
Giulio MolonCardiology Department, IRCCS Sacro Cuore Don Calabria Hospital, Negrar, Italy.ORCID https://orcid.org/0000-0001-8287-0461
Federico AlbericiNephrology Unit, ASST degli Spedali Civili di Brescia, Brescia, Italy.ORCID https://orcid.org/0000-0002-1686-5709
Marianna AdamoCardiology Unit, ASST degli Spedali Civili di Brescia, Brescia, Italy.ORCID https://orcid.org/0000-0002-3855-1815
Achille GaspardoneCardiology Unit, S.Eugenio Hospital, Roma, Italy.
Giuseppe D'AngeloCardiac Pacing Unit, IRCCS Ospedale San Raffaele, Milano, Italy.
Pierluigi MerellaCardiology Unit, Azienda Ospedaliera Universitaria di Sassari, Sassari, Italy.
Giuseppe VezzoliNephrology Unit, IRCCS Ospedale San Raffaele, Milano, Italy.
Barbara TrezziSchool of Medicine and Surgery, University of Milano-Bicocca, Monza, Italy.
Patrizio MazzoneCardiology 3, "A. De Gasperis" Cardio Center, ASST GOM Niguarda Ca' Granda, Milan, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: The prevalence of atrial fibrillation (AF) in end stage kidney disease (ESKD) patients undergoing dialysis is high, however, the high risk of bleeding often hampers with a correct anticoagulation in ESKD patients with AF, despite high thromboembolic risk. Left atrial appendage (LAA) occlusion is a anticoagulation (OAT) for thromboembolism prevention in AF populations with high hemorrhagic risk. Methods and Results: The purpose of the study was to evaluate the efficacy and safety of LAA occlusion in a cohort of dialysis patients undergoing the procedure (LAA occlusion cohort, Conclusion: In ESKD patients with AF, LAA occlusion is safe and effective and is associated with reduced mortality compared with OAT or no therapy.

Indexed as

atrial fibrillationbleedingend stage kidney diseaseleft atrial appendage occlusionthromboembolism

Identifiers

PMID38046009
PMCPMC10689152

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.