ArticleClinical kidney journal2023
The impact of gender on the risk of cardiovascular events in older adults with advanced chronic kidney disease.
Article in Clinical kidney journal, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- Kidney replacement therapy for men and women according to the ERA Registry and the USRDS.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2026Article
- Prognostic Value of Claims Data for Chronic Kidney Disease-Associated Health Risks.Kidney & blood pressure research · 2026Article
- Exploring prognostic factors on vascular outcomes among maintenance dialysis patients and establishing a prognosis prediction model using machine learning methods.BMC medical informatics and decision making · 2025Article
- Sex Differences in Cardiovascular Diseases and Vascular Function in Chronic Kidney Disease.Cardiology clinics · 2025Review
- Differential cardiovascular risk profiles by sex among adults with CKD: a NHANES-based analysis.Frontiers in cardiovascular medicine · 2025Article
- Cardiovascular Disease in Chronic Kidney Disease: Implications of Cardiorespiratory Fitness, Race, and Sex.Reviews in cardiovascular medicine · 2024Review
- Kynurenine Pathway after Kidney Transplantation: Friend or Foe?International journal of molecular sciences · 2024Review
- Sixty years of European Renal Association (ERA) Registry data on kidney disease: visualizing differences in clinical practice.Clinical kidney journal · 2024Article
- Sex disparities in mortality and cardiovascular outcomes in chronic kidney disease.Clinical kidney journal · 2024Review
- Functional Fitness Norms of Community-Dwelling Older Adults in Southern Rural Taiwan: A Cross-Sectional Study.Healthcare (Basel, Switzerland) · 2024Article
- Cardiovascular disease in older women with CKD.Clinical kidney journal · 2023Article
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Authors and funding
15 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Patients with chronic kidney disease (CKD) are at a higher risk of major adverse cardiovascular events (MACE) compared with the general population, but gender differences in this risk, especially in older adults, are not fully known. We aim to identify gender differences in the risk of MACE in older European CKD patients, and explore factors that may explain these differences. Methods: The European Quality study (EQUAL) is a prospective study on stage 4-5 CKD patients, ≥65 years old, not on dialysis, from Germany, Italy, the Netherlands, Poland, Sweden and the UK. Cox regression and cumulative incidence competing risk curves were used to identify gender differences in MACE risks. Mediation analysis was used to identify variables which may explain risk differences between men and women. Results: A total of 417 men out of 1134 (37%) and 185 women out of 602 women (31%) experienced at least one MACE, over a follow-up period of 5 years. Women had an 18% lower risk of first MACE compared with men (hazard ratio 0.82; 95% confidence interval 0.69-0.97; Conclusions: In a cohort of older adults with advanced CKD, women had lower risks of MACE. These risk differences were partially explained by pre-existing cardiometabolic comorbidities and cardiovascular risk factors.
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