Evidence map›Paper›PMID 38045825›Full record

ArticleRespirology case reports2024

Improving visual acuity with nivolumab plus ipilimumab plus two cycles of chemotherapy following a diagnosis of lung adenocarcinoma with choroidal metastasis: A case report and literature review.

Takahiro Matsuyama, Masashi Oniwa, Kentaro Tsuruzono, Shunsuke Yasuda, Mikiko Yone, Yuya Tomioka, Akifumi Uchida, Hideo Mitsuyama, Shingo Kubota, Takayuki Suetsugu and 2 more

Abstract readCase Reports
In one paragraph

Article in Respirology case reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Takahiro MatsuyamaDepartment of Respiratory Medicine Kagoshima University Graduate School of Medical and Dental Sciences Kagoshima Japan.ORCID https://orcid.org/0009-0009-5167-8579
Masashi OniwaDepartment of Respiratory Medicine Kagoshima University Graduate School of Medical and Dental Sciences Kagoshima Japan.
Kentaro TsuruzonoDepartment of Respiratory Medicine Kagoshima University Graduate School of Medical and Dental Sciences Kagoshima Japan.
Shunsuke YasudaDepartment of Respiratory Medicine Kagoshima University Graduate School of Medical and Dental Sciences Kagoshima Japan.
Mikiko YoneDepartment of Respiratory Medicine Kagoshima University Graduate School of Medical and Dental Sciences Kagoshima Japan.
Yuya TomiokaDepartment of Respiratory Medicine Kagoshima University Graduate School of Medical and Dental Sciences Kagoshima Japan.
Akifumi UchidaDepartment of Respiratory Medicine Kagoshima University Graduate School of Medical and Dental Sciences Kagoshima Japan.
Hideo MitsuyamaDepartment of Respiratory Medicine Kagoshima University Graduate School of Medical and Dental Sciences Kagoshima Japan.
Shingo KubotaDepartment of Respiratory Medicine Kagoshima University Graduate School of Medical and Dental Sciences Kagoshima Japan.
Takayuki SuetsuguDepartment of Respiratory Medicine Kagoshima University Graduate School of Medical and Dental Sciences Kagoshima Japan.
Keiko MizunoDepartment of Respiratory Medicine Kagoshima University Graduate School of Medical and Dental Sciences Kagoshima Japan.
Hiromasa InoueDepartment of Respiratory Medicine Kagoshima University Graduate School of Medical and Dental Sciences Kagoshima Japan.ORCID https://orcid.org/0000-0001-8080-3812

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A 75-year-old woman presented at our hospital with bilateral visual impairment. Ophthalmological examination revealed multiple choroidal tumours. Chest computed tomography revealed a tumour shadow in the right lower lobe and multiple lymph node metastases in the mediastinum and pulmonary hilum. Following a detailed examination, the patient was diagnosed with primary lung adenocarcinoma (cT1cN3M1c Stage IVB) with choroid metastases. The tumour proportion score of programmed death ligand 1 (PD-L1) was 1% and EGFR exon 20 insertion mutations were also detected. The patient was administered combination chemotherapy with nivolumab and ipilimumab. Primary lung and metastatic tumours, including the choroid, were reduced, and visual disturbances improved completely. Herein, we describe a rare case in which a combination of chemotherapy with nivolumab and ipilimumab significantly reduced vision loss due to choroidal metastasis.

Indexed as

choroidal metastasisipilimumabnivolumabnon‐small cell lung cancervision loss

Identifiers

PMID38045825
PMCPMC10687591

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.