Evidence map›Paper›PMID 38045756›Full record

ArticleAdvanced electronic materials2023

Wirelessly Powered-Electrically Conductive Polymer System for Stem Cell Enhanced Stroke Recovery.

Sruthi Santhanam, Cheng Chen, Byeongtaek Oh, Kelly W McConnell, Matine M Azadian, Jainith J Patel, Emily E Gardner, Yuji Tanabe, Ada S Y Poon, Paul M George

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced electronic materials, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Sruthi SanthanamDepartment of Neurology and Neurological Sciences, Stanford University School of Medicine, 300 Pasteur Dr., MC5778, Stanford, CA 94305, USA.
Cheng ChenDepartment of Electrical Engineering, Stanford University, 350 Jane Stanford Way, Stanford, CA 94305, USA.
Byeongtaek OhDepartment of Neurology and Neurological Sciences, Stanford University School of Medicine, 300 Pasteur Dr., MC5778, Stanford, CA 94305, USA.
Kelly W McConnellDepartment of Neurology and Neurological Sciences, Stanford University School of Medicine, 300 Pasteur Dr., MC5778, Stanford, CA 94305, USA.
Matine M AzadianDepartment of Neurology and Neurological Sciences, Stanford University School of Medicine, 300 Pasteur Dr., MC5778, Stanford, CA 94305, USA.
Jainith J PatelDepartment of Neurology and Neurological Sciences, Stanford University School of Medicine, 300 Pasteur Dr., MC5778, Stanford, CA 94305, USA.
Emily E GardnerDepartment of Neurology and Neurological Sciences, Stanford University School of Medicine, 300 Pasteur Dr., MC5778, Stanford, CA 94305, USA.
Yuji TanabeDepartment of Electrical Engineering, Stanford University, 350 Jane Stanford Way, Stanford, CA 94305, USA.
Ada S Y PoonDepartment of Electrical Engineering, Stanford University, 350 Jane Stanford Way, Stanford, CA 94305, USA.
Paul M GeorgeDepartment of Neurology and Neurological Sciences, Stanford University School of Medicine, 300 Pasteur Dr., MC5778, Stanford, CA 94305, USA.

Funding

A Conductive Polymer-Stem Cell System to Augment Endogenous Stroke Repair Mechanisms and Improve Functional Stroke RecoveryR01NS126761 · NINDS · STANFORD UNIVERSITY · PI Paul George · 2023 to 2026
$1.5M
Optimizing Stem Cell-Enhanced Stroke Recovery through a Bioengineered Electrically Conductive Polymer ScaffoldK08NS089976 · NINDS · STANFORD UNIVERSITY · PI GEORGE, PAUL · 2015 to 2019
$940k
NINDS NIH HHS K08 NS089976NINDS NIH HHS R01 NS126761
6 · The paper itself

Abstract

Effective stroke recovery therapeutics remain limited. Stem cell therapies have yielded promising results, but the harsh ischemic environment of the post-stroke brain reduces their therapeutic potential. Previously, we developed a conductive polymer scaffold system that enabled stem cell delivery with simultaneous electrical modulation of the cells and surrounding neural environment. This wired polymer scaffold proved efficacious in optimizing ideal conditions for stem cell mediated motor improvements in a rodent model of stroke. To further enable preclinical studies and enhance translational potential, we identified a method to improve this system by eliminating its dependence upon a tethered power source. We have herein developed a wirelessly powered, electrically conductive polymer system that eases therapeutic application and enables full mobility. As a proof of concept, we demonstrate that the wirelessly powered scaffold is able to stimulate neural stem cells

Indexed as

implantable stimulatorspolymer scaffoldsstem cell therapystroke recoverywireless powering

Identifiers

PMID38045756
PMCPMC10691593

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.