Evidence map›Paper›PMID 38045702›Full record

ArticleFrontiers in immunology2023

Impact of SARS-CoV-2 vaccination on FcγRIIIA/CD16 dynamics in Natural Killer cells: relevance for antibody-dependent functions.

Cristina Capuano, Davide De Federicis, Daniel Ciuti, Ombretta Turriziani, Antonio Angeloni, Emanuela Anastasi, Giuseppe Giannini, Francesca Belardinilli, Rosa Molfetta, Domenico Alvaro and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.8field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 1 country.

Cristina Capuano *Departmental Faculty of Medicine and Surgery, UniCamillus-Saint Camillus International University of Health and Medical Sciences, Rome, Italy.
Davide De Federicis *Department of Experimental Medicine, Sapienza University of Rome, Rome, Italy.
Daniel CiutiDepartment of Experimental Medicine, Sapienza University of Rome, Rome, Italy.
Ombretta TurrizianiDepartment of Molecular Medicine, Sapienza University of Rome, Rome, Italy.
Antonio AngeloniDepartment of Experimental Medicine, Sapienza University of Rome, Rome, Italy.
Emanuela AnastasiDepartment of Experimental Medicine, Sapienza University of Rome, Rome, Italy.
Giuseppe GianniniDepartment of Molecular Medicine, Sapienza University of Rome, Rome, Italy.
Francesca BelardinilliDepartment of Molecular Medicine, Sapienza University of Rome, Rome, Italy.
Rosa MolfettaDepartment of Molecular Medicine, Sapienza University of Rome, Rome, Italy.
Domenico AlvaroDepartment of Translational and Precision Medicine, Sapienza University of Rome, Rome, Italy.
Gabriella Palmieri *Department of Experimental Medicine, Sapienza University of Rome, Rome, Italy.
Ricciarda Galandrini *Department of Experimental Medicine, Sapienza University of Rome, Rome, Italy.
Sapienza University of Rome · ITSaint Camillus International University of Health and Medical Sciences · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Natural Killer (NK) cells contribute to the protective effects of vaccine-induced antibodies thanks to the low affinity receptor for IgG, FcγRIIIA/CD16, whose aggregation leads to the killing of infected cells and IFNγ release, through which they potentiate adaptive immune responses. Methods: Forty-seven healthy young individuals undergoing either homologous (ChAdOx1-S/ChAdOx1-S) or heterologous (ChAdOx1-S/BNT162B2) SARS-CoV-2 vaccination settings were recruited. Peripheral blood samples were collected immediately prior to vaccination and 8 weeks after the booster dose. The phenotypic and functional profile of NK cells was evaluated by flow cytometry at both time points. Serum samples were tested to evaluate circulating anti-Spike IgG levels and cytomegalovirus serostatus. CD16 F158V polymorphism was assessed by sequencing analysis. Results: The downregulation of CD16 and the selective impairment of antibody-dependent cytotoxicity and IFNγ production in CD56 Conclusion: This study demonstrates a durable downmodulation of CD16 levels and Ab-dependent NK functions after SARS-CoV-2 heterologous vaccination, and highlights the impact of genetic and environmental host-related factors in modulating NK cell susceptibility to post-vaccinal Fc-dependent functional impairment.

Indexed as

COVID-19COVID-19 VaccinesAntibodies, ViralAntibody-Dependent Cell CytotoxicityBNT162 VaccineHumansImmunoglobulin GKiller Cells, NaturalSARS-CoV-2VaccinationAntibodies, ViralBNT162 VaccineCOVID-19 VaccinesImmunoglobulin GADCCCD16CD16 polymorphismIFNγmemory NK cellsNK cellsSARS-CoV-2 vaccine

Identifiers

PMID38045702
PMCPMC10693335
OpenAlexW4388797135

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.