ArticlePhysics and imaging in radiation oncology2023
Accurate, repeatable, and geometrically precise diffusion-weighted imaging on a 0.35 T magnetic resonance imaging-guided linear accelerator.
Article in Physics and imaging in radiation oncology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- The role of diffusion-weighted MRI in biological image-guided radiation therapy: a roadmap.Physics in medicine and biology · 2026Review
- Adaptation of an arterial spin labeling sequence for the assessment of brain perfusion on a 0.35 T MR-Linac.Magma (New York, N.Y.) · 2026Article
- Acceptance testing of a 0.35 T MR-Linac: procedures, QA baseline, and system limitations.Journal of applied clinical medical physics · 2026Article
- Multi-center diffusion-weighted MRI validation for 0.35T MR-Linac.Physica medica : PM : an international journal devoted to the applications of physics to medicine and biology : official journal of the Italian Association of Biomedical Physics (AIFB) · 2026Article
- Diffusion-weighted imaging-derived parameters as quantitative imaging biomarkers in magnetic resonance-guided radiotherapy: a systematic review.Physics and imaging in radiation oncology · 2025Review
- Open-source quality assurance for multi-parametric MRI: a diffusion analysis update for the magnetic resonance biomarker assessment software (MR-BIAS).Magma (New York, N.Y.) · 2025Article
- Innovative approaches in precision radiation oncology: advanced imaging technologies and challenges which shape the future of radiation therapy.Frontiers in medicine · 2025Review
- Optimal Setup and Parameters of Diffusion-Weighted Magnetic Resonance Imaging for Translational Evaluation of a Tumor Progression Model for Soft Tissue Sarcomas.Advances in radiation oncology · 2025Article
- Validation of echo planar imaging based diffusion-weighted magnetic resonance imaging on a 0.35 T MR-Linac.Physics and imaging in radiation oncology · 2024Article
- Repeatability quantification of brain diffusion-weighted imaging for future clinical implementation at a low-field MR-linac.Radiation oncology (London, England) · 2024Article
- Review
- Addressing the Knowledge Gap in Magnetic Resonance Imaging Physics in Türkiye: A Transcontinental Continuing Educational Initiative by the Turkish Medical Physics Association.Journal of medical physicsArticle
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Authors and funding
16 authors.
Funding
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Abstract
Background and purpose: Diffusion weighted imaging (DWI) allows for the interrogation of tissue cellularity, which is a surrogate for cellular proliferation. Previous attempts to incorporate DWI into the workflow of a 0.35 T MR-linac (MRL) have lacked quantitative accuracy. In this study, accuracy, repeatability, and geometric precision of apparent diffusion coefficient (ADC) maps produced using an echo planar imaging (EPI)-based DWI protocol on the MRL system is illustrated, and Materials and methods: Accuracy and repeatability were assessed by measuring ADC values in a diffusion phantom at three timepoints and comparing to reference ADC values. System-dependent geometric distortion was quantified by measuring the distance between 93 pairs of phantom features on ADC maps acquired on a 0.35 T MRL and a 3.0 T diagnostic scanner and comparing to spatially precise CT images. Additionally, for five sarcoma patients receiving radiotherapy on the MRL, same-day Results: Phantom ADC quantification was accurate on the 0.35 T MRL with significant discrepancies only seen at high ADC. Average geometric distortions were 0.35 (±0.02) mm and 0.85 (±0.02) mm in the central slice and 0.66 (±0.04) mm and 2.14 (±0.07) mm at 5.4 cm off-center for the MRL and diagnostic system, respectively. In the sarcoma patients, a mean pretreatment ADC of 910x10 Conclusions: The acquisition of accurate, repeatable, and geometrically precise ADC maps is possible at 0.35 T with an EPI approach.
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