ArticleCritical care and resuscitation : journal of the Australasian Academy of Critical Care Medicine2022
Protocol and statistical analysis plan for the mega randomised registry trial research program comparing conservative versus liberal oxygenation targets in adults receiving unplanned invasive mechanical ventilation in the ICU (Mega-ROX).
Article in Critical care and resuscitation : journal of the Australasian Academy of Critical Care Medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
33 citing papers in PubMed, 2 syntheses or guidelines pooled it, 40 citations in OpenAlex.
- Conservative Oxygen Targets in Mechanically Ventilated Patients (OXY-BREATHES): A Systematic Review and Meta-Analysis of Randomized Controlled Trials.Critical care medicine · 2026Pooled it
- ADJUNCTIVE VASOPRESSORS AND SHORT-TERM MORTALITY IN ADULTS WITH SEPTIC SHOCK: A SYSTEMATIC REVIEW AND META-ANALYSIS.Shock (Augusta, Ga.) · 2025Pooled it
- Conservative versus liberal oxygenation targets in critically ill children: the Oxy-PICU RCT.Health technology assessment (Winchester, England) · 2026Trial
- Trial
- Early Restrictive vs Liberal Oxygen for Trauma Patients: The TRAUMOX2 Randomized Clinical Trial.JAMA · 2025Trial
- Conservative versus Liberal Oxygenation Targets in Intensive Care Unit Patients (ICONIC): A Randomized Clinical Trial.American journal of respiratory and critical care medicine · 2023Trial
- Oxygen targets and 6-month outcome after out of hospital cardiac arrest: a pre-planned sub-analysis of the targeted hypothermia versus targeted normothermia after Out-of-Hospital Cardiac Arrest (TTM2) trial.Critical care (London, England) · 2022Trial
- Early Arterial Oxygen Tension Thresholds for Mechanically Ventilated Patients with Non-traumatic Acute Brain Injury: A Bayesian Analysis of Three Large Neurocritical Care Datasets.Neurocritical care · 2026Article
- Conservative versus liberal oxygen therapy in hypoxic ischemic encephalopathy following cardiac arrest: a trial-based cost-effectiveness analysis.Resuscitation plus · 2026Article
- Conservative oxygenation strategy may increase ventilator-free days for critically ill patients in intensive care unit.Journal of intensive medicine · 2026Article
- Sample size requirements and intra-cluster correlations for stepped wedge cluster randomised trials in intensive care medicine: A practical guide.Critical care and resuscitation : journal of the Australasian Academy of Critical Care Medicine · 2026Article
- Heterogeneity and confounding in the TRAUMOX2 randomised clinical trial-a reply.Annals of translational medicine · 2026Article
- Beyond one-size-fits-all: Addressing patient heterogeneity through precision-based oxygen therapy research in critical care.Journal of intensive medicine · 2026Article
- [Focus on emergency medicine 2024/2025 : Summary of selected studies in emergency medicine].Die Anaesthesiologie · 2026Article
- Oxygen therapy in the intensive care unit.Medical gas research · 2025Review
- A study of Professor Bellomo's contribution to cardiac arrest research.Critical care and resuscitation : journal of the Australasian Academy of Critical Care Medicine · 2025Article
- Restrictive Oxygen Use Did Not Improve Outcomes in the UK ROX Study.Acta anaesthesiologica Scandinavica · 2025Article
- Early restrictive versus liberal oxygen for trauma patients: does it make a difference?Annals of translational medicine · 2025Article
- Excessive vasopressors or excessive hypotension: Searching for the goldilocks zone in mean arterial pressure targets.Critical care and resuscitation : journal of the Australasian Academy of Critical Care Medicine · 2025Article
- Mean arterial pressure targets in intensive care unit patients receiving noradrenaline: An international survey.Critical care and resuscitation : journal of the Australasian Academy of Critical Care Medicine · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
17 authors at 9 institutions in 7 countries.
Funding
Abstract
PubMed holds no abstract for this paper.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.