ArticleCritical care and resuscitation : journal of the Australasian Academy of Critical Care Medicine2021
Interference by piperacillin/tazobactam in the measurement of creatinine with the Jaffe method and of total protein with the biuret method.
Article in Critical care and resuscitation : journal of the Australasian Academy of Critical Care Medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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4 citing papers in PubMed.
- Evaluation of the interference of 49 commonly used clinical drugs on 60 biochemical tests.Practical laboratory medicine · 2026Article
- Strengthening the interpretation of longitudinal EQA data through the sporadic inclusion of native human sera in general clinical chemistry.Frontiers in molecular biosciences · 2026Article
- The Key Enzymes of Carbon Metabolism and the Glutathione Antioxidant System ProtectJournal of fungi (Basel, Switzerland) · 2024Article
- Plasma concentration and eGFR in preterm and term neonates receiving gentamicin or successive amikacin therapy.BMC pediatrics · 2023Article
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2 authors.
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Abstract
Serum creatinine and total protein are routinely measured biochemical parameters used in clinical medicine. An abnormal result caused by interference with the assay does not accurately reflect a patient's clinical state and therefore risks misleading clinicians. We report the case of a patient who had unexplainable high creatinine and total protein results. The blood collection was contaminated with intravenous fluid and the patient was receiving piperacillin/tazobactam. Additional laboratory studies demonstrated piperacillin/tazobactam was the cause of the false positive results and the elevation in both serum creatinine and protein level was dependent on the concentration of antibiotic present.
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