Evidence map›Paper›PMID 38045379›Full record

ArticlebioRxiv : the preprint server for biology2024

Parvalbumin interneuron mGlu

Carly B Fabian, Nilah D Jordan, Rebecca H Cole, Lily G Carley, Shannon M Thompson, Marianne L Seney, Max E Joffe

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 2 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Carly B FabianDepartment of Psychiatry, University of Pittsburgh, Pittsburgh, PA, 15219, USA.
Nilah D JordanCenter for Neuroscience University of Pittsburgh, Pittsburgh, PA.
Rebecca H ColeDepartment of Psychiatry, University of Pittsburgh, Pittsburgh, PA, 15219, USA.
Lily G CarleyDepartment of Psychiatry, University of Pittsburgh, Pittsburgh, PA, 15219, USA.
Shannon M ThompsonDepartment of Psychiatry, University of Pittsburgh, Pittsburgh, PA, 15219, USA.
Marianne L SeneyDepartment of Psychiatry, University of Pittsburgh, Pittsburgh, PA, 15219, USA.
Max E JoffeDepartment of Psychiatry, University of Pittsburgh, Pittsburgh, PA, 15219, USA.
University of Pittsburgh · US

Funding

Predoctorial Training in Basic NeuroscienceT32NS007433 · NINDS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI MERINEY, STEPHEN D · 1998 to 2022
$8.0M
Sex-specific dendritic spine and microglia pathology in depressionR01MH120066 · NIMH · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI SENEY, MARIANNE L · 2019 to 2023
$1.9M
Sex differences in fast-spiking interneurons promote AUD-related PFC dysfunction: remediation by modulating mGlu1 and mGlu5 - Supplement RevR00AA027806 · NIAAA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI JOFFE, MAX E · 2021 to 2023
$826k
NIAAA NIH HHS R00 AA027806NIMH NIH HHS R01 MH120066NINDS NIH HHS T32 NS007433
6 · The paper itself

Abstract

Despite established sex differences in the prevalence and presentation of psychiatric disorders, little is known about the cellular and synaptic mechanisms that guide these differences under basal conditions. Proper function of the prefrontal cortex (PFC) is essential for the top-down regulation of motivated behaviors. Activity of the PFC is tightly controlled by parvalbumin-expressing interneurons (PV-INs), a key subpopulation of fast-spiking GABAergic cells that regulate cortical excitability through direct innervations onto the perisomatic regions of nearby pyramidal cells. Recent rodent studies have identified notable sex differences in PV-IN activity and adaptations to experiences such as binge drinking. Here, we investigated the cellular and molecular mechanisms that underlie sex-specific regulation of PFC PV-IN function. Using whole-cell patch clamp electrophysiology and selective pharmacology, we report that PV-INs from female mice are more excitable than those from males. Moreover, we find that mGlu

Indexed as

addictionalcoholcognitionGABAG protein-coupled receptor (GPCR)prefrontal cortex

Identifiers

PMID38045379
PMCPMC10690210
OpenAlexW4388852606

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.