Evidence map›Paper›PMID 38045376›Full record

ArticleResearch square2023

Macrophages modulate fibrosis during newt lens regeneration.

Georgios Tsissios, Anthony Sallese, J Raul Perez-Estrada, Jared A Tangeman, Weihao Chen, Byran Smucker, Sophia C Ratvasky, Erika L Grajales-Esquive, Arielle Martinez, Kimberly J Visser and 5 more

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in Research square, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

15 authors at 1 institution in 3 countries.

Georgios TsissiosMiami University.ORCID 0000-0002-5219-616X
Anthony SalleseMiami University.
J Raul Perez-EstradaMiami University.
Jared A TangemanMiami University.
Weihao ChenMiami University.
Byran SmuckerMiami University.
Sophia C RatvaskyMiami University.
Erika L Grajales-EsquiveMiami University.
Arielle MartinezMiami University.
Kimberly J VisserDresden University of Technology: Technische Universitat Dresden.
Alberto Joven ArausKarolinska Institute: Karolinska Institutet.
Hui WangMiami University.
Andras SimonKarolinska Institute: Karolinska Institutet.
Maximina H YunDresden University of Technology: Technische Universitat Dresden.
Katia Del Rio-TsonisMiami University.ORCID 0000-0002-3051-6716
Karolinska Institutet · SE

Funding

On Determinants of Lens RegenerationR01EY027801 · NEI · MIAMI UNIVERSITY OXFORD · PI DEL RIO-TSONIS, KATIA · 2017 to 2019
$1.1M
Inflammation is a driver of newt lens regenerationR21EY033916 · NEI · MIAMI UNIVERSITY OXFORD · PI DEL RIO-TSONIS, KATIA · 2022 to 2023
$397k
In vivo imaging of newt lens regeneration: Novel molecular, cellular and functional insightsR21EY031865 · NEI · MIAMI UNIVERSITY OXFORD · PI DEL RIO-TSONIS, KATIA, WANG, HUI · 2020 to 2021
$383k
Elucidating the gene regulatory networks that drive neural regenerationF99NS129167 · NINDS · MIAMI UNIVERSITY OXFORD · PI TANGEMAN, JARED A · 2022 to 2022
$41k
NEI NIH HHS R01 EY027801NEI NIH HHS R21 EY031865NEI NIH HHS R21 EY033916NINDS NIH HHS F99 NS129167
6 · The paper itself

Abstract

Background: Previous studies indicated that macrophages play a role during lens regeneration in newts, but their function has not been tested experimentally. Methods: Here we generated a transgenic newt reporter line in which macrophages can be visualized Results: Macrophage depletion induced the formation of scar-like tissue, an increased and sustained inflammatory response, an early decrease in iris pigment epithelial cell (iPEC) proliferation and a late increase in apoptosis. Some of these phenotypes persisted for at least 100 days and could be rescued by exogenous FGF2. Re-injury alleviated the effects of macrophage depletion and re-started the regeneration process. Conclusions: Together, our findings highlight the importance of macrophages in facilitating a pro-regenerative environment in the newt eye, helping to resolve fibrosis, modulating the overall inflammatory landscape and maintaining the proper balance of early proliferation and late apoptosis.

Indexed as

inflammationLens regenerationmacrophagetissue repair

Identifiers

PMID38045376
PMCPMC10690311
OpenAlexW4388994217

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.