Evidence map›Paper›PMID 38045229›Full record

ArticlemedRxiv : the preprint server for health sciences2023

Is Catheter Ablation Associated with Preservation of Cognitive Function? An Analysis From the SAGE-AF Observational Cohort Study.

Bahadar S Srichawla, Alexander P Hamel, Philip Cook, Rozaleen Aleyadeh, Darleen Lessard, Edith M Otabil, Jordy Mehawej, Jane S Saczynski, David D McManus, Majaz Moonis

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in medRxiv : the preprint server for health sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors.

Bahadar S SrichawlaDepartment of Neurology, University of Massachusetts Chan Medical School, Worcester, MA, U.S.A.ORCID 0000-0002-5301-4102
Alexander P HamelDepartment of Medicine, University of Massachusetts Chan Medical School, Worcester, MA, U.S.A.ORCID 0000-0002-5855-6912
Philip CookDepartment of Medicine, University of Massachusetts Chan Medical School, Worcester, MA, U.S.A.ORCID 0000-0002-7791-7998
Rozaleen AleyadehDepartment of Neurology, University of Massachusetts Chan Medical School, Worcester, MA, U.S.A.ORCID 0000-0002-9995-5012
Darleen LessardDepartment of Medicine, University of Massachusetts Chan Medical School, Worcester, MA, U.S.A.
Edith M OtabilDepartment of Medicine, University of Massachusetts Chan Medical School, Worcester, MA, U.S.A.
Jordy MehawejDepartment of Medicine, University of Massachusetts Chan Medical School, Worcester, MA, U.S.A.
Jane S SaczynskiDepartment of Medicine, University of Massachusetts Chan Medical School, Worcester, MA, U.S.A.
David D McManusDepartment of Medicine, University of Massachusetts Chan Medical School, Worcester, MA, U.S.A.ORCID 0000-0002-9343-6203
Majaz MoonisDepartment of Neurology, University of Massachusetts Chan Medical School, Worcester, MA, U.S.A.ORCID 0000-0002-9747-0003

Funding

The Center for Advancing Point of Care in Heart, Lung, Blood and Sleep DiseasesU54HL143541 · NHLBI · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI BRYAN O BUCHHOLZ, Nathaniel Scott Hafer · 2018 to 2026
$141.0M
A phase I trial of AdKCNH2-G628S gene therapy for post-op atrial fibrillationR33HL158541 · NHLBI · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI DONAHUE, J KEVIN, MCMANUS, DAVID D. · 2022 to 2023
$3.4M
SUPPORT-AF IVR01HL155343 · NHLBI · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI KAPOOR, ALOK · 2021 to 2025
$3.4M
Systematic Assessment of Geriatric Elements in Atrial Fibrillation (SAGE-AF)R01HL126911 · NHLBI · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI MCMANUS, DAVID D., SACZYNSKI, JANE STEELE · 2016 to 2019
$3.2M
FHS-NEXT - Framingham Novel EXam using TechnologyR01HL141434 · NHLBI · BOSTON UNIVERSITY MEDICAL CAMPUS · PI BENJAMIN, EMELIA J., MCMANUS, DAVID D. · 2019 to 2022
$2.5M
NHLBI NIH HHS R01 HL126911NHLBI NIH HHS R01 HL141434NHLBI NIH HHS R01 HL155343NHLBI NIH HHS R33 HL158541NHLBI NIH HHS U54 HL143541
6 · The paper itself

Abstract

Objectives: To examine the associations between catheter ablation treatment (CA) versus medical management and cognitive impairment among older adults with atrial fibrillation (AF). Methods: Ambulatory patients who had AF, were ≥ 65-years-old, and were eligible to receive oral anticoagulation could be enrolled into the SAGE (Systematic Assessment of Geriatric Elements)-AF study from internal medicine and cardiology clinics in Massachusetts and Georgia between 2016 and 2018. Cognitive function was assessed using the Montreal Cognitive Assessment (MoCA) tool at baseline, one-, and two years. Cognitive impairment was defined as a MoCA score ≤ 23. Multivariate-adjusted logistic regression of longitudinal repeated measures was used to examine associations between treatment with CA vs. medical management and cognitive impairment. Results: 887 participants were included in this analysis. On average, participants were 75.2 ± 6.7 years old, 48.6% women, and 87.4% white non-Hispanic. 193 (21.8%) participants received a CA before enrollment. Participants who had previously undergone CA were significantly less likely to be cognitively impaired during the two-year study period ( Conclusions: In this two-year longitudinal prospective cohort study participants who underwent CA for AF before enrollment were less likely to have cognitive impairment than those who had not undergone CA.

Indexed as

ablationatrial fibrillationcognitive functionhemorrhageinfarctionstroke

Identifiers

PMID38045229
PMCPMC10690357

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.