ArticlebioRxiv : the preprint server for biology2024
Hammerhead-type FXR agonists induce an eRNA
Jinjing Chen, Ruoyu Wang, Feng Xiong, Hao Sun, Byron Kemper, Wenbo Li, Jongsook Kim Kemper
Open access · greenAbstract readPreprint
In one paragraphArticle in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
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3 · Its place in the literatureWho cites it
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4 · The recordCorrections and comments
5 · Who and what moneyAuthors and funding
7 authors at 2 institutions in 1 country.
Jinjing ChenDepartment of Molecular and Integrative Physiology, University of Illinois at Urbana-Champaign, Urbana, IL, USA.
Ruoyu WangDepartment of Biochemistry and Molecular Biology, McGovern Medical School, University of Texas Health Science Center, Houston, TX, USA.
Feng XiongDepartment of Biochemistry and Molecular Biology, McGovern Medical School, University of Texas Health Science Center, Houston, TX, USA.
Hao SunDepartment of Molecular and Integrative Physiology, University of Illinois at Urbana-Champaign, Urbana, IL, USA.
Byron KemperDepartment of Molecular and Integrative Physiology, University of Illinois at Urbana-Champaign, Urbana, IL, USA.
Wenbo LiDepartment of Biochemistry and Molecular Biology, McGovern Medical School, University of Texas Health Science Center, Houston, TX, USA.
Jongsook Kim KemperDepartment of Molecular and Integrative Physiology, University of Illinois at Urbana-Champaign, Urbana, IL, USA.ORCID 0000-0002-5534-0286 University of Illinois Urbana-Champaign · USThe University of Texas Health Science Center at Houston · US
Funding
Regulation of Cholesterol Catabolism by Bile AcidsR01DK062777 · NIDDK · UNIVERSITY OF ILLINOIS URBANA-CHAMPAIGN · PI KEMPER, JONGSOOK KIM · 2003 to 2021
$5.8MCoordination of gut-liver bile acid signaling by FXRR01DK095842 · NIDDK · UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN · PI KEMPER, JONGSOOK KIM · 2012 to 2021
$3.0MMechanisms Underlying Enhancer Rnp Mediated Gene Regulation And Genome OrganizationR01GM136922 · NIGMS · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI LI, WENBO · 2020 to 2024
$2.0MCondensin-mediated enhancer and chromatin architectural control of breast cancer gene transcriptionK22CA204468 · NCI · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI LI, WENBO · 2017 to 2019
$486kOptogenetic Engineering of 3D Chromatin ArchitectureR21GM132778 · NIGMS · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI LI, WENBO · 2019 to 2020
$434kNCI NIH HHS K22 CA204468NIDDK NIH HHS R01 DK062777NIDDK NIH HHS R01 DK095842NIGMS NIH HHS R01 GM136922NIGMS NIH HHS R21 GM132778NLM NIH HHS HHSN276201200017C
6 · The paper itselfAbstract
The nuclear receptor, Farnesoid X Receptor (FXR/NR1H4), is increasingly recognized as a promising drug target for metabolic diseases, including nonalcoholic steatohepatitis (NASH). Protein coding genes regulated by FXR are well known, but whether FXR also acts through regulation of long non-coding RNAs (lncRNAs), which vastly outnumber protein-coding genes, remains unknown. Utilizing RNA-seq and GRO-seq analyses in mouse liver, we found that FXR activation affects the expression of many RNA transcripts from chromatin regions bearing enhancer features. Among these we discovered a previously unannotated liver-enriched enhancer-derived lncRNA (eRNA), termed
Indexed as
enhancerenhancer RNAFXRGro-seqhepatic inflammationlncRNANAFLDNASHnuclear receptorRNA-seqtropifexor
Identifiers
PMID38045226
PMCPMC10690184
OpenAlexW4388868717
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