Evidence map›Paper›PMID 38045211›Full record

ArticleHeliyon2023

Ferulated Poly(vinyl alcohol) based hydrogels.

Simone Pepi, Marco Paolino, Mario Saletti, Jacopo Venditti, Luigi Talarico, Marco Andreassi, Germano Giuliani, Gianfranco Caselli, Roberto Artusi, Andrea Cappelli and 3 more

Abstract read
In one paragraph

Article in Heliyon, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Simone PepiDipartimento di Biotecnologie, Chimica e Farmacia (Dipartimento di Eccellenza 2018-2022), Università Degli Studi di Siena, Via A. Moro 2, 53100, Siena, Italy.
Marco PaolinoDipartimento di Biotecnologie, Chimica e Farmacia (Dipartimento di Eccellenza 2018-2022), Università Degli Studi di Siena, Via A. Moro 2, 53100, Siena, Italy.
Mario SalettiDipartimento di Biotecnologie, Chimica e Farmacia (Dipartimento di Eccellenza 2018-2022), Università Degli Studi di Siena, Via A. Moro 2, 53100, Siena, Italy.
Jacopo VendittiDipartimento di Biotecnologie, Chimica e Farmacia (Dipartimento di Eccellenza 2018-2022), Università Degli Studi di Siena, Via A. Moro 2, 53100, Siena, Italy.
Luigi TalaricoDipartimento di Biotecnologie, Chimica e Farmacia (Dipartimento di Eccellenza 2018-2022), Università Degli Studi di Siena, Via A. Moro 2, 53100, Siena, Italy.
Marco AndreassiDipartimento di Biotecnologie, Chimica e Farmacia (Dipartimento di Eccellenza 2018-2022), Università Degli Studi di Siena, Via A. Moro 2, 53100, Siena, Italy.
Germano GiulianiDipartimento di Biotecnologie, Chimica e Farmacia (Dipartimento di Eccellenza 2018-2022), Università Degli Studi di Siena, Via A. Moro 2, 53100, Siena, Italy.
Gianfranco CaselliRottapharm Biotech, Via Valosa di Sopra 7, 20052, Monza, Italy.
Roberto ArtusiRottapharm Biotech, Via Valosa di Sopra 7, 20052, Monza, Italy.
Andrea CappelliDipartimento di Biotecnologie, Chimica e Farmacia (Dipartimento di Eccellenza 2018-2022), Università Degli Studi di Siena, Via A. Moro 2, 53100, Siena, Italy.
Gemma LeoneDipartimento di Biotecnologie, Chimica e Farmacia (Dipartimento di Eccellenza 2018-2022), Università Degli Studi di Siena, Via A. Moro 2, 53100, Siena, Italy.
Agnese MagnaniDipartimento di Biotecnologie, Chimica e Farmacia (Dipartimento di Eccellenza 2018-2022), Università Degli Studi di Siena, Via A. Moro 2, 53100, Siena, Italy.
Lucio RovatiRottapharm Biotech, Via Valosa di Sopra 7, 20052, Monza, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

New graft copolymers were prepared by reaction of poly (vinyl alcohol) (PVA) with mono-imidazolide or bis-imidazolide derivatives of ferulic acid (FA) with the formation of ester bonds. The obtained graft copolymers, thanks to the crosslinking capability of FA, formed in water strong gels as verified by rheological analyses. The resulting hydrogels were characterized to evaluate their applicability as wound dressing. In this perspective, their capability to absorb and retain a large amount of fluid without dissolving was verified by swelling kinetics and Moisture Vapour Transmission Rate measurements. Their stability towards mechanical solicitations was assessed by quantifying elasticity, compliance, stress-relaxation, and adhesivity properties. The analyses pointed out that hydrogel PVA-FA2-3 obtained by feruloylation of PVA with bis-imidazole derivative of ferulic acid using an acylation agent/polymer molar ratio 0.03/1 resulted the best candidate for the foreseen application.

Indexed as

Ferulic acidHydrogelpoly(vinyl alcohol) (PVA)RheologyWound dressing

Identifiers

PMID38045211
PMCPMC10692910

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.