Evidence map›Paper›PMID 38045012›Full record

ArticleVeterinary and animal science2023

Stevia as a natural additive on gut health and cecal microbiota in broilers.

Daniela B Medeot, Armando Nilson, Raul D Miazzo, Viviana Grosso, Walter Ferrari, Edgardo Jofré, Arnaldo Soltermann, María Fernanda Peralta

Abstract read
In one paragraph

Article in Veterinary and animal science, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Daniela B MedeotLaboratorio de Biología Molecular de las Interacciones Planta-Bacteria-Instituto de Biotecnología Ambiental y de Salud (INBIAS)- Universidad Nacional de Rio Cuarto (UNRC)-Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET) UNRC: ruta 36 Km 601-5800-Rio Cuarto, Córdoba, Argentina.
Armando NilsonUnidad de Investigación Aviar, Producción Avícola, Facultad de Agronomía y Veterinaria-UNRC, Argentina.
Raul D MiazzoUnidad de Investigación Aviar, Producción Avícola, Facultad de Agronomía y Veterinaria-UNRC, Argentina.
Viviana GrossoLaboratorio de Vinculación Tecnológica, Facultad de Ciencias Exactas, Físico-Químicas y Naturales-UNRC, Argentina.
Walter FerrariLaboratorio de Biología Molecular de las Interacciones Planta-Bacteria-Instituto de Biotecnología Ambiental y de Salud (INBIAS)- Universidad Nacional de Rio Cuarto (UNRC)-Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET) UNRC: ruta 36 Km 601-5800-Rio Cuarto, Córdoba, Argentina.
Edgardo JofréLaboratorio de Biología Molecular de las Interacciones Planta-Bacteria-Instituto de Biotecnología Ambiental y de Salud (INBIAS)- Universidad Nacional de Rio Cuarto (UNRC)-Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET) UNRC: ruta 36 Km 601-5800-Rio Cuarto, Córdoba, Argentina.
Arnaldo SoltermannLaboratorio de Vinculación Tecnológica, Facultad de Ciencias Exactas, Físico-Químicas y Naturales-UNRC, Argentina.
María Fernanda PeraltaUnidad de Investigación Aviar, Producción Avícola, Facultad de Agronomía y Veterinaria-UNRC, Argentina.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Stevia mash (SM), leaves of Stevia rebaudiana Bertoni plant, is an additive used in poultry that enhances growth and health. Objective: to determine the effect of 1 % SM on productive parameters, gut health, and the cecal microbiome in broilers between the first 15 and 21 days old. One hundred sixty male, 1-day-old broilers (48.5 ± 2.5 g) were divided into Control (C) without SM and Treated (T) with 1 % SM on diet, during 15/21 days. Each subgroup had eight broilers/five repetitions/treatment. At day 15 or 21, all broilers were dissected, Fabricius Bursa and Gut removed and processed for histomorphometry, followed by Villi Height/Crypt Deep (VH/CD) ratio. Conversion Index (CI) was determined. The V3-V4 region of 16S rRNA gene was amplified from DNA obtained from pooled cecal contents and sequenced on Illumina Miseq PE 2 × 250 platform. Sequence processing and taxonomic assignments were performed using the SHAMAN pipeline. Both T groups have better VH/CD Ratios than C groups (p ≤ 0.05). In guts, increased plasmatic and goblet cells number and thicker mucus layer were found in T15 and T21. All groups received SM showed early immunological maturity in Fabricius Bursa. IC was similar between all treatments. Faecalibacterium, Ruminococcus torques group, and Bacteroides were the major genera modulated by SM addition. At 15 and 21 days old, SM exerts a impact on diversity and evenness of the cecal microbiome.  Conclusion: SM (1 %) produced early immunologic maturity on Fabricius Bursa, increased intestinal functionality, and modified the microbiota, increasing beneficial microbial genera and microbial diversity.

Indexed as

Alternative to antibioticsBroiler chickenCecal MetagenomicGut healthStevia

Identifiers

PMID38045012
PMCPMC10692954

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.