Evidence map›Paper›PMID 38044468›Full record

ArticlePediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society

Diminished

Przemyslaw Szafranski, Silvia Patrizi, Tomasz Gambin, Bushra Afzal, Emily Schlotterbeck, Justyna A Karolak, Gail Deutsch, Drucilla Roberts, Paweł Stankiewicz

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. The Glu86 Residue in TBX4 Proves Critical for Human Lung Development.American journal of medical genetics. Part A · 2025
    Article
  5. Pediatric Diffuse Lung Disease in Infants: Imaging Findings and Histopathologic Correlation.Radiographics : a review publication of the Radiological Society of North America, Inc · 2024
    Review
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Przemyslaw SzafranskiDepartment of Molecular & Human Genetics, Baylor College of Medicine, Houston, TX, USA.
Silvia PatriziDepartment of Pediatrics, Division of Neonatology, Brigham and Women's Hospital and Newton-Wellesley Hospital, Harvard Medical School, Boston, MA, USA.
Tomasz GambinInstitute of Computer Science, Warsaw University of Technology, Warsaw, Poland.
Bushra AfzalDepartment of Pediatrics, Division of Neonatology, Brigham and Women's Hospital and Newton-Wellesley Hospital, Harvard Medical School, Boston, MA, USA.
Emily SchlotterbeckDepartment of Pathology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
Justyna A KarolakChair and Department of Genetics and Pharmaceutical Microbiology, Poznan University of Medical Sciences, Poznan, Wielkopolskie, Poland.
Gail DeutschDepartment of Laboratory Medicine and Pathology, University of Washington School of Medicine, Seattle, WA, USA.
Drucilla RobertsDepartment of Pathology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
Paweł StankiewiczDepartment of Molecular & Human Genetics, Baylor College of Medicine, Houston, TX, USA.

Funding

Etiology and pathogenesis of lethal lung developmental disorders in neonatesR01HL165301 · NHLBI · BAYLOR COLLEGE OF MEDICINE · PI PAWEL STANKIEWICZ · 2023 to 2026
$3.1M
NHLBI NIH HHS R01 HL165301
6 · The paper itself

Abstract

Acinar dysplasia (AcDys) of the lung is a rare lethal developmental disorder in neonates characterized by severe respiratory failure and pulmonary arterial hypertension refractory to treatment. Recently, abnormalities of TBX4-FGF10-FGFR2-TMEM100 signaling regulating lung development have been reported in patients with AcDys due to heterozygous single-nucleotide variants or copy-number variant deletions involving

Indexed as

Membrane ProteinsT-Box Domain ProteinsAcinar CellsFatal OutcomeFemaleHumansInfant, NewbornLungMutation, MissenseMembrane ProteinsT-Box Domain ProteinsTBX4 protein, humanTMEM100 protein, humanlethal lung developmental disorderneonatepathogenic single nucleotide variantpulmonary arterial hypertensionT-box transcription factor

Identifiers

PMID38044468
PMCPMC11087193

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.