Evidence map›Paper›PMID 38044439›Full record

Observational studyJournal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance2023

Technical development and feasibility of a reusable vest to integrate cardiovascular magnetic resonance with electrocardiographic imaging.

Matthew Webber, George Joy, Jonathan Bennett, Fiona Chan, Debbie Falconer, Hunain Shiwani, Rhodri H Davies, Gunther Krausz, Slobodan Tanackovic, Christoph Guger and 17 more

Registry-linked trialAbstract readObservational Study
In one paragraph

Observational study in Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05455125 (A Cardiac Sub-Study of the MRC National Survey of Health and Development), which is not on this map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05455125 unknown statusnot on this map

A Cardiac Sub-Study of the MRC National Survey of Health and Development (NSHD)

TypeobservationalSponsorUniversity College, LondonRan2020 to 2024Enrolled550ConditionsFrailty, Cardiovascular DiseasesArmsCMR CGI
3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Variant patterns of electrical activation and recovery in normal human hearts revealed by noninvasive electrocardiographic imaging.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2024
    Article
  3. Article
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

27 authors.

Matthew WebberBarts Heart Centre, Barts Health NHS Trust, West Smithfield, London, ECIA 7BE, UK.
George JoyBarts Heart Centre, Barts Health NHS Trust, West Smithfield, London, ECIA 7BE, UK.
Jonathan BennettBarts Heart Centre, Barts Health NHS Trust, West Smithfield, London, ECIA 7BE, UK.
Fiona ChanBarts Heart Centre, Barts Health NHS Trust, West Smithfield, London, ECIA 7BE, UK.
Debbie FalconerCentre for Inherited Heart Muscle Conditions, Department of Cardiology, Royal Free London NHS Foundation Trust, Pond Street, London, NW3 2QG, UK.
Hunain ShiwaniBarts Heart Centre, Barts Health NHS Trust, West Smithfield, London, ECIA 7BE, UK.
Rhodri H DaviesBarts Heart Centre, Barts Health NHS Trust, West Smithfield, London, ECIA 7BE, UK.
Gunther Krauszg.Tec Medical Engineering GmbH, Siernigtrabe 14, 4521, Schiedlberg, Austria.
Slobodan Tanackovicg.Tec Medical Engineering GmbH, Siernigtrabe 14, 4521, Schiedlberg, Austria.
Christoph Gugerg.Tec Medical Engineering GmbH, Siernigtrabe 14, 4521, Schiedlberg, Austria.
Pablo GonzalezELEM Biotech, S.L, Barcelona, Spain.
Emma MartinMedical Research Council Unit for Lifelong Health and Ageing at UCL, University College London, 1-19 Torrington Place, London, WC1E 7HB, UK.
Andrew WongMedical Research Council Unit for Lifelong Health and Ageing at UCL, University College London, 1-19 Torrington Place, London, WC1E 7HB, UK.
Alicja RapalaMedical Research Council Unit for Lifelong Health and Ageing at UCL, University College London, 1-19 Torrington Place, London, WC1E 7HB, UK.
Kenan DirekMedical Research Council Unit for Lifelong Health and Ageing at UCL, University College London, 1-19 Torrington Place, London, WC1E 7HB, UK.
Peter KellmanNational Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, 20892, USA.
Iain PierceBarts Heart Centre, Barts Health NHS Trust, West Smithfield, London, ECIA 7BE, UK.
Yoram RudyCardiac Bioelectricity and Arrhythmia Center, Washington University, St. Louis, MO, 63130, USA.
Ramya VijayakumarCardiac Bioelectricity and Arrhythmia Center, Washington University, St. Louis, MO, 63130, USA.
Nishi ChaturvediInstitute of Cardiovascular Science, University College London, Huntley Street, London, WC1E 6DD, UK.
Alun D HughesInstitute of Cardiovascular Science, University College London, Huntley Street, London, WC1E 6DD, UK.
James C MoonBarts Heart Centre, Barts Health NHS Trust, West Smithfield, London, ECIA 7BE, UK.
Pier D LambiaseBarts Heart Centre, Barts Health NHS Trust, West Smithfield, London, ECIA 7BE, UK.
Xuyuan TaoÉcole Nationale Supérieure des Arts et Industries Textiles, 2 allée Louise et Victor Champier, 59056, Roubaix CEDEX 1, France.
Vladan KoncarÉcole Nationale Supérieure des Arts et Industries Textiles, 2 allée Louise et Victor Champier, 59056, Roubaix CEDEX 1, France.
Michele Orini *Institute of Cardiovascular Science, University College London, Huntley Street, London, WC1E 6DD, UK.
Gabriella Captur *Institute of Cardiovascular Science, University College London, Huntley Street, London, WC1E 6DD, UK. gabriella.captur@ucl.ac.uk.ORCID 0000-0002-5662-0642

Funding

British Heart Foundation FS/CRTF/21/24269British Heart Foundation SP/20/2/3841Medical Research Council MC_UU_00019/1Medical Research Council MC_UU_00019/2Medical Research Council MC_UU_00019/3MRF MC_UU_0019/1,2,3
6 · The paper itself

Abstract

backgroundElectrocardiographic imaging (ECGI) generates electrophysiological (EP) biomarkers while cardiovascular magnetic resonance (CMR) imaging provides data about myocardial structure, function and tissue substrate. Combining this information in one examination is desirable but requires an affordable, reusable, and high-throughput solution. We therefore developed the CMR-ECGI vest and carried out this technical development study to assess its feasibility and repeatability in vivo.

methodsCMR was prospectively performed at 3T on participants after collecting surface potentials using the locally designed and fabricated 256-lead ECGI vest. Epicardial maps were reconstructed to generate local EP parameters such as activation time (AT), repolarization time (RT) and activation recovery intervals (ARI). 20 intra- and inter-observer and 8 scan re-scan repeatability tests.

results77 participants were recruited: 27 young healthy volunteers (HV, 38.9 ± 8.5 years, 35% male) and 50 older persons (77.0 ± 0.1 years, 52% male). CMR-ECGI was achieved in all participants using the same reusable, washable vest without complications. Intra- and inter-observer variability was low (correlation coefficients [r

conclusionOur high-throughput CMR-ECGI solution is feasible and shows good reproducibility in younger and older participants. This new technology is now scalable for high throughput research to provide novel insights into arrhythmogenesis and potentially pave the way for more personalised risk stratification. CLINICAL

trial registrationTitle: Multimorbidity Life-Course Approach to Myocardial Health-A Cardiac Sub-Study of the MRC National Survey of Health and Development (NSHD) (MyoFit46). National Clinical Trials (NCT) number: NCT05455125. URL: https://clinicaltrials.gov/ct2/show/NCT05455125?term=MyoFit&draw=2&rank=1.

Indexed as

HeartMagnetic Resonance ImagingAdultAgedFeasibility StudiesFemaleHumansMagnetic Resonance SpectroscopyMaleMiddle AgedPredictive Value of TestsReproducibility of ResultsCardiovascular magnetic resonance imagingElectrocardiographic imagingElectrophysiologyFeasibilityReproducibility

Identifiers

PMID38044439
PMCPMC10694972

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.