Evidence map›Paper›PMID 38044425›Full record

Observational studyScandinavian journal of trauma, resuscitation and emergency medicine2023

The effect of restrictive versus liberal selection criteria on survival in ECPR: a retrospective analysis of a multi-regional dataset.

Arne Diehl, Andrew C Read, Timothy Southwood, Hergen Buscher, Mark Dennis, Vinodh Bhagyalakshmi Nanjayya, Aidan J C Burrell

Abstract readMulticenter StudyObservational Study
In one paragraph

Observational study in Scandinavian journal of trauma, resuscitation and emergency medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Arne DiehlDepartment of Intensive Care and Hyperbaric Medicine, The Alfred Hospital, Commercial Road, Melbourne, Australia. a.diehl@alfred.org.au.ORCID http://orcid.org/0000-0003-2983-8707
Andrew C ReadDepartment of Intensive Care, St Vincent's Hospital, Sydney, Australia.
Timothy SouthwoodDepartment of Intensive Care, Royal Prince Alfred Hospital, Sydney, Australia.
Hergen BuscherDepartment of Intensive Care, St Vincent's Hospital, Sydney, Australia.
Mark DennisDepartment of Cardiology, Royal Prince Alfred Hospital, Sydney, Australia.
Vinodh Bhagyalakshmi NanjayyaDepartment of Intensive Care and Hyperbaric Medicine, The Alfred Hospital, Commercial Road, Melbourne, Australia.
Aidan J C BurrellDepartment of Intensive Care and Hyperbaric Medicine, The Alfred Hospital, Commercial Road, Melbourne, Australia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundExtracorporeal cardiopulmonary resuscitation (ECPR) is an established rescue therapy for both out-of-hospital cardiac arrest (OHCA) and in-hospital cardiac arrest (IHCA). However, there remains significant heterogeneity in populations and outcomes across different studies. The primary aim of this study was to compare commonly used selection criteria and their effect on survival and utilisation in an Australian ECPR cohort.

methodsWe performed a retrospective, observational study of three established ECPR centres in Australia, including cases from 1 January 2013 to 31 December 2020 to establish the baseline cohort. We applied five commonly used ECPR selection criteria, ranging from restrictive to liberal.

resultsThe baseline cohort included 199 ECPR cases: 95 OHCA and 104 IHCA patients. Survival to hospital discharge was 20% for OHCA and 41.4% for IHCA. For OHCA patients, strictly applying the most restrictive criteria would have resulted in the highest survival rate 7/16 (43.8%) compared to the most liberal criteria 16/73 (21.9%). However, only 16/95 (16.8%) in our cohort strictly met the most restrictive criteria versus 73/95 (76.8%) with the most liberal criteria. Similarly, in IHCA, the most restrictive criteria would have resulted in a higher survival rate in eligible patients 10/15 (66.7%) compared to 27/59 (45.8%) with the most liberal criteria. With all criteria a large portion of survivors in IHCA would not have been eligible for ECMO if strictly applying criteria, 33/43 (77%) with restrictive and 16/43 (37%) with the most liberal criteria.

conclusionsAdherence to different selection criteria impacts both the ECPR survival rate and the total number of survivors. Commonly used selection criteria may be unsuitable to select IHCA ECPR patients.

Indexed as

Cardiopulmonary ResuscitationExtracorporeal Membrane OxygenationOut-of-Hospital Cardiac ArrestAustraliaHumansPatient SelectionRetrospective StudiesTreatment OutcomeCardiac arrestECMOECPRExtracorporeal membrane oxygenationIn-hospital cardiac arrestOut-of-hospital cardiac arrest

Identifiers

PMID38044425
PMCPMC10694924

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.