Evidence map›Paper›PMID 38044022›Full record

ArticleThe American journal of clinical nutrition2023

Associations of dietary patterns between age 9 and 24 months with risk of celiac disease autoimmunity and celiac disease among children at increased risk.

Elin M Hård Af Segerstad, Lazarus K Mramba, Xiang Liu, Ulla Uusitalo, Jimin Yang, Jill Norris, Suvi M Virtanen, Edwin Liu, Kalle Kurppa, Sibylle Koletzko and 8 more

Open access · hybridAbstract read
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In one paragraph

Article in The American journal of clinical nutrition, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
2.2field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 8 citations in OpenAlex.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

18 authors at 10 institutions in 5 countries.

Elin M Hård Af SegerstadDepartment of Clinical Sciences, Lund University, Malmö, Sweden. Electronic address: elin.malmberg_hard_af_segerstad@med.lu.se.
Lazarus K MrambaDepartment of Pediatrics, Health Informatics Institute, Morsani Collage of Medicine, University of South Florida, Tampa, FL, United States.
Xiang LiuDepartment of Pediatrics, Health Informatics Institute, Morsani Collage of Medicine, University of South Florida, Tampa, FL, United States.
Ulla UusitaloDepartment of Pediatrics, Health Informatics Institute, Morsani Collage of Medicine, University of South Florida, Tampa, FL, United States.
Jimin YangDepartment of Pediatrics, Health Informatics Institute, Morsani Collage of Medicine, University of South Florida, Tampa, FL, United States.
Jill NorrisDepartment of Epidemiology, Colorado School of Public Health, University of Colorado, Aurora, CO, United States.
Suvi M VirtanenDepartment of Public Health and Welfare, Finnish Institute for Health and Welfare, Helsinki, Finland; Unit of Health Sciences, Faculty of Social Sciences, Tampere University, Tampere, Finland; Tampere Center for Child, Adolescent and Maternal Health Research, Tampere University and Tampere University Hospital, Tampere, Finland.
Edwin LiuChildren's Hospital Colorado, University of Colorado Denver, Aurora, CO, United States.
Kalle KurppaTampere Center for Child, Adolescent and Maternal Health Research, Tampere University and Tampere University Hospital, Tampere, Finland; Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland; The University Consortium of Seinäjoki, Seinäjoki, Finland.
Sibylle KoletzkoDepartment of Paediatrics, Dr. von Hauner Children's Hospital, University Hospital, LMU Munich, Munich, Germany; Department of Paediatrics, Gastroenterology and Nutrition, School of Medicine Collegium Medicum University of Warmia and Mazury, Olsztyn, Poland.
Annette G ZieglerKlinikum Rechts der Isar, Technische Universität München, München, Bayern, Germany; Institute of Diabetes Research, Helmholtz Zentrum München, Germany; Forschergruppe Diabetes e.V, Neuherberg, Germany.
Jorma ToppariResearch Centre for Integrative Physiology and Pharmacology, Institute of Biomedicine, University of Turku, Turku, Finland; Department of Paediatrics, Turku University Hospital, Turku, Finland.
Marian RewersBarbara Davis Center for Childhood Diabetes, University of Colorado, Aurora, CO, United States.
Beena AkolkarNational Institute of Diabetes and Digestive and Kidney Disease, National Institutes of Health, Bethesda, MD, United States.
Jeffrey P KrischerDepartment of Pediatrics, Health Informatics Institute, Morsani Collage of Medicine, University of South Florida, Tampa, FL, United States.
Carin Andrén AronssonDepartment of Clinical Sciences, Lund University, Malmö, Sweden.
Daniel AgardhDepartment of Clinical Sciences, Lund University, Malmö, Sweden.
TEDDY study group
University of South Florida · USLund University · SETampere University · FIChildren's Hospital Colorado · USColorado School of Public Health · USNational Institutes of Health · USTUM Klinikum · DEUniversity of Colorado Anschutz Medical Campus · USUniversity of Turku · FIUniversity of Warmia and Mazury in Olsztyn · PL

Funding

Limited Competition: Continued Follow-up of Subjects and Initiation of a Second Case-control Cohort in The Environmental Determinants of Diabetes in The Young Study (TEDDY)U01DK128847 · NIDDK · UNIVERSITY OF SOUTH FLORIDA · PI JEFFREY P KRISCHER · 2021 to 2026
$79.2M
NIDDK NIH HHS U01 DK128847
6 · The paper itself

Abstract

backgroundHigher gluten intake in childhood is associated with increased incidence of celiac disease autoimmunity (CDA) and celiac disease. It remains to be studied whether different dietary patterns independent of gluten intake contribute to the incidence.

objectivesThis study aimed to explore associations of dietary patterns by age 2 y with risk of CDA and celiac disease in genetically susceptible children.

methodsData was used from 6726 participants at genetic risk of type 1 diabetes and celiac disease enrolled in the observational cohort, The Environmental Determinants of Diabetes in the Young (TEDDY) study. Children were annually screened for tissue transglutaminase autoantibodies (tTGAs) from age 2 y. Principal component analysis extracted dietary patterns, based on intake of 27 food groups assessed by 3-d food records at age 9 to 24 mo. The primary outcome was CDA (i.e., persistently tTGA-positive in at least 2 consecutive samples), and the secondary outcome was celiac disease. During follow-up to mean age 11.0 (standard deviation 3.6) y, 1296 (19.3%) children developed CDA, and 529 (7.9%) were diagnosed with celiac disease. Associations of adherence to dietary patterns (per 5-unit increase) with the study outcomes were estimated by Cox regression models adjusted for risk factors including gluten intake.

resultsAt age 9 mo, a dietary pattern higher in the food groups vegetable fats and milk was associated with reduced risk of CDA (hazard ratio [HR]: 0.88; 95% confidence interval [CI]: 0.79, 0.98; P = 0.02). At 24 mo, a dietary pattern higher in the food groups wheat, vegetable fats, and juices, and lower in milk, meat, and oats at age 24 mo was associated with increased risk of CDA (HR: 1.18; 95% CI: 1.05, 1.33; P < 0.001) and celiac disease (HR: 1.24; 95% CI: 1.03, 1.50; P = 0.03).

conclusionsDietary patterns in early childhood are associated with risk of CDA and celiac disease in genetically predisposed children, independent of gluten intake.

Indexed as

Celiac DiseaseAdolescentAdultAutoantibodiesAutoimmunityChildChild, PreschoolGenetic Predisposition to DiseaseGlutensHumansInfantTransglutaminasesYoung AdultAutoantibodiesGlutensTransglutaminasesceliac diseaseceliac disease autoimmunitycomplementary feedingdietary patternsglutenHLA-DQ2/DQ8infant dietprincipal component analysisTEDDY

Identifiers

PMID38044022
PMCPMC10925856
OpenAlexW4387666272

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.