Evidence map›Paper›PMID 38043705›Full record

ArticleJournal of vascular and interventional radiology : JVIR2024

Clinical Utility of Infrapopliteal Calcium Score for the Evaluation of Severity of Peripheral Artery Disease.

Sujin Lee, Mari Tanaka, Shiv Patel, Nikolaos Zacharias, Sandeep Hedgire, Rajeev Malhotra, Anahita Dua

Open access · greenAbstract read
In one paragraph

Article in Journal of vascular and interventional radiology : JVIR, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.6field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Peripheral Vascular Calcification.Arteriosclerosis, thrombosis, and vascular biology · 2026
    Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Sujin LeeDivision of Vascular Surgery and Endovascular Therapy, Department of Surgery, Massachusetts General Hospital, Boston, Massachusetts. Electronic address: slee@mgh.harvard.edu.
Mari TanakaDivision of Interventional Radiology Department of Radiology, Massachusetts General Hospital, Boston, Massachusetts.
Shiv PatelDivision of Vascular Surgery and Endovascular Therapy, Department of Surgery, Massachusetts General Hospital, Boston, Massachusetts.
Nikolaos ZachariasDivision of Vascular Surgery and Endovascular Therapy, Department of Surgery, Massachusetts General Hospital, Boston, Massachusetts.
Sandeep HedgireDivision of Cardiovascular Imaging, Department of Radiology, Massachusetts General Hospital, Boston, Massachusetts.
Rajeev MalhotraCardiology Division, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts.
Anahita DuaDivision of Vascular Surgery and Endovascular Therapy, Department of Surgery, Massachusetts General Hospital, Boston, Massachusetts.
Massachusetts General Hospital · US

Funding

The Role of Histone Deacetylase 9 in Vascular CalcificationR01HL142809 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI MALHOTRA, RAJEEV · 2018 to 2022
$4.0M
The Role of Arylsulfatase in Vascular CalcificationR01HL162928 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI PAUL STEFAN DE VRIES, Rajeev Malhotra · 2023 to 2026
$2.6M
Characterization of Functional Iron Deficiency and Repletion in Heart Failure with Preserved Ejection FractionR01HL159514 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI LEWIS, GREGORY DYER, MALHOTRA, RAJEEV · 2021 to 2024
$2.5M
Novel Molecular Regulators of Vascular CalcificationF32HL164025 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI LEE, SUJIN · 2023 to 2024
$164k
NHLBI NIH HHS F32 HL164025NHLBI NIH HHS R01 HL142809NHLBI NIH HHS R01 HL162928
6 · The paper itself

Abstract

purposeTo identify associations between computed tomography (CT)-based lower-extremity calcium score (LECS) across different anatomic segments and the presence, severity, and clinical outcomes of peripheral artery disease (PAD). MATERIALS AND

methodsIn a mixed retrospective and prospective cohort study, 139 patients without prior lower-extremity intervention who underwent CT angiography of the aorta and lower extremities were identified. Subjects were classified as asymptomatic, claudicants, or having chronic limb-threatening ischemia (CLTI). LECS was measured using the Agatston method. Univariate and multivariate analyses were performed across categories of PAD severity. Receiver operating characteristic (ROC) analysis was performed, and an optimal cutoff point for LECS was identified. Claudicants were followed prospectively for CLTI and mortality.

resultsHigher infrapopliteal calcium score (CS) was independently associated with CLTI versus claudication (odds ratio [OR], 3.24 per unit increase in log

conclusionsHigher infrapopliteal CS was associated with CLTI among those with symptomatic PAD. An infrapopliteal CS cutoff of 188 Agatston units may serve as a useful tool to identify patients with increased risk of CLTI and mortality.

Indexed as

CalciumPeripheral Arterial DiseaseChronic DiseaseHumansIntermittent ClaudicationIschemiaLimb SalvageProspective StudiesRetrospective StudiesRisk FactorsTreatment OutcomeCalcium

Identifiers

PMID38043705
PMCPMC11179150
OpenAlexW4389265694

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.