ArticleBrazilian journal of anesthesiology (Elsevier)
Association between preoperative anemia optimization and major complications after non-cardiac surgery: a retrospective analysis.
Article in Brazilian journal of anesthesiology (Elsevier). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed, 7 citations in OpenAlex.
- Postoperative Blood Transfusion as an Independent Predictor of Morbidity and Mortality After Carotid Endarterectomy: A Single-Centre Retrospective Cohort Study.Journal of clinical medicine · 2026Article
- Bidirectional Relationship Between Systemic Immune-Inflammation Index and Postoperative Pneumonia in Elderly Patients Undergoing Colorectal Cancer Surgery: A Retrospective Cohort Study.Clinical interventions in aging · 2026Article
- Article
- "Detect Anemia Preoperatively": A Scoping Review of Recommendations.Annals of surgery open : perspectives of surgical history, education, and clinical approaches · 2025Review
- Vasopressors in obstetrics: guidelines and good practice.Journal of anesthesia · 2024Article
Corrections and comments
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Authors and funding
11 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAnemia is common in the preoperative setting and associated with increased postoperative complications and mortality. However, it is unclear if preoperative anemia optimization reduces postoperative complications. We aimed to assess the association between preoperative anemia optimization and a composite endpoint of major cardiovascular, renal, and pulmonary complications and all-cause mortality within 30 days after noncardiac surgery in adult patients.
methodsIn this retrospective analysis preoperative anemia was defined as hemoglobin concentration below 12.0 g.dl
resultsFifty-seven hundred anemia optimized, and 8721 non-optimized patients met study criteria. The proportion of patients having any component of the composite of major complications and all-cause mortality was 21.5% in the anemia-optimized versus 18.0% in the non-optimized, with confounder-adjusted odds ratio estimate of 0.99 (95% CI 0.86‒1.15) for anemia optimization versus non-optimization, p = 0.90. Intraoperative red blood cell transfusion had a minor mediation effect on the relationship between preoperative anemia optimization and the primary outcome, whereas duration of intraoperative hypotension was not found to be a mediator.
conclusionPreoperative anemia optimization did not appear to be associated with a composite outcome of major in-hospital postoperative cardiovascular, renal, and pulmonary complications and all-cause in-hospital mortality.
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