Evidence map›Paper›PMID 38043509›Full record

ArticleNephron2024

Urine Uromodulin, Kidney Tubulointerstitial Fibrosis, and Furosemide Response.

Alexander L Bullen, Sucheta Vaingankar, Magdalena Madero, Salvador Lopez Gil, Etienne Macedo, Joachim H Ix, Dena E Rifkin, Pranav S Garimella

Abstract readNews
PubMed Full text at PMC Publisher
In one paragraph

Article in Nephron, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Salt and chronic kidney disease.Nature reviews. Nephrology · 2026
    Review
  2. Article
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Alexander L BullenNephrology Section, Veterans Affairs San Diego Healthcare System, La Jolla, California, USA.
Sucheta VaingankarDivision of Nephrology-Hypertension, Department of Medicine, University of California San Diego, San Diego, California, USA.
Magdalena MaderoNephrology Department, National Institute Cardiology Ignacio Chávez, Mexico City, Mexico.
Salvador Lopez GilNephrology Department, Centro Médico ABC Observatorio, Colonia Las Americas, Álvaro Obregón, Mexico City, Mexico.
Etienne MacedoDivision of Nephrology-Hypertension, Department of Medicine, University of California San Diego, San Diego, California, USA.
Joachim H IxNephrology Section, Veterans Affairs San Diego Healthcare System, La Jolla, California, USA.
Dena E RifkinNephrology Section, Veterans Affairs San Diego Healthcare System, La Jolla, California, USA.
Pranav S GarimellaDivision of Nephrology-Hypertension, Department of Medicine, University of California San Diego, San Diego, California, USA.

Funding

UAB-UCSD O'Brien Core Center for Acute Kidney Injury ResearchP30DK079337 · NIDDK · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI AGARWAL, ANUPAM · 2008 to 2022
$18.3M
Tubular secretion, kidney disease progression, and drug dosing in older adultsK23DK114556 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI GARIMELLA, PRANAV · 2018 to 2022
$1.0M
Mentored Patient Oriented Research in Kidney DiseaseK24DK110427 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI IX, JOACHIM H · 2016 to 2020
$780k
Kidney Tubule Cell Function and Future Risk of Acute Kidney InjuryIK2BX004986 · VA · VA SAN DIEGO HEALTHCARE SYSTEM · PI Alexander Lionel Bullen · 2020 to 2026
–
BLRD VA IK2 BX004986NIDDK NIH HHS K23 DK114556NIDDK NIH HHS K24 DK110427NIDDK NIH HHS P30 DK079337
6 · The paper itself

Abstract

backgroundInterstitial fibrosis and tubular atrophy (IFTA) are common findings on biopsy in chronic kidney disease (CKD) and are strongly predictive of kidney failure. IFTA is poorly correlated with estimated glomerular filtration rate (eGFR) and albuminuria, the most common measures of kidney function. Thus, IFTA is prognostically important, yet its presence and severity are invisible to the clinician except when kidney biopsies are obtained.

objectivesThe objective of this study was to investigate (1) the cross-sectional association between urine uromodulin (uUMOD) and IFTA and (2) to determine whether uUMOD levels were associated with diuretic response after a furosemide stress test.

methodsWe performed logistic regression to evaluate the association between uUMOD and fibrosis. We used linear regression models to assess the association of uUMOD with diuretic response.

resultsAmong 52 participants, the mean age was 42 ± 16 years, 48% were women, 23% had diabetes, and the median eGFR was 56 mL/min/1.73 m2. The mean uUMOD concentration was 5.1 (8.4) μg/mL. Each halving of uUMOD was associated with 1.74 higher odds (95% CI: 1.10, 2.75) of grade 2 or 3 fibrosis. However, this association was no longer significant after adjusting for baseline eGFR and albuminuria. Each halving of uUMOD was associated with a decreased response to furosemide. This association was also no longer significant after adjusting for baseline eGFR and albuminuria.

conclusionIn a population of individuals with a wide range of kidney function undergoing clinically indicated kidney biopsies, we did not find an association between uUMOD and interstitial fibrosis or response to loop diuretics after adjusting for eGFR and albuminuria.

Indexed as

DiureticsFibrosisFurosemideGlomerular Filtration RateUromodulinAdultCross-Sectional StudiesFemaleHumansKidneyKidney TubulesMaleMiddle AgedRenal Insufficiency, ChronicDiureticsFurosemideUromodulinBiomarkerChronic kidney diseaseFibrosisFurosemide stress testUromodulin

Identifiers

PMID38043509
PMCPMC11216347

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.