Trial reportDrug and alcohol dependence2024
A preliminary randomized controlled trial of repetitive transcranial magnetic stimulation applied to the left dorsolateral prefrontal cortex in treatment seeking participants with cannabis use disorder.
Trial report in Drug and alcohol dependence, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed, 13 citations in OpenAlex.
- High-frequency repetitive transcranial magnetic stimulation is associated with sustained improvement in cannabis use disorder: a one-year, two-phase, three-arm randomized study.Frontiers in psychiatry · 2026Trial
- Behavioral and Functional Neuroimaging Effects of Delivering a Course of Repetitive Transcranial Magnetic Stimulation to Personalized Targets Within the Ventrolateral Or Dorsolateral Prefrontal Cortex in Treatment-Seeking Participants with Cannabis Use Disorder.medRxiv : the preprint server for health sciences · 2026Article
- Utilizing multimodal cortical parcellations to identify novel regions of the human cerebral cortex associated with substance use disorders.Molecular psychiatry · 2026Article
- Article
- The Role of Repetitive Transcranial Magnetic Stimulation in Treating Alcohol Use Disorder: Neural Mechanisms, Efficacy, and Future Directions.Alpha psychiatry · 2025Review
- Repetitive transcranial magnetic stimulation for substance use disorders and chronic pain: A review of the evidence and call for increased mechanistic understanding.Current addiction reports · 2025Article
- Rewiring recovery: Patient-centered neuromodulation interventions for substance use disorders that meet people where they are.Transcranial magnetic stimulation (2024) · 2025Article
- Exploring the Utility of a Functional Magnetic Resonance Imaging Cannabis Cue-Reactivity Paradigm in Treatment-Seeking Adults With Cannabis Use Disorder.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2025Article
- Sex differences in normative modeling of cortical thickness in cannabis use disorder.Drug and alcohol dependence reports · 2025Article
- A Secondary Analysis Suggests That Repetitive Transcranial Magnetic Stimulation Applied to the Left Dorsolateral Prefrontal Cortex Reduces Cue-Induced-Craving in Treatment Seeking Participants with Cannabis Use Disorder.medRxiv : the preprint server for health sciences · 2025Article
- rTMS for Co-occurring Psychiatric and Substance Use Disorders: Narrative Review and Future Directions.Current addiction reports · 2024Article
- Transcranial Magnetic Stimulation as a Tool to Promote Smoking Cessation and Decrease Drug and Alcohol Use.Brain sciences · 2023Review
Corrections and comments
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Authors and funding
18 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundCannabis use disorder (CUD) is a common and consequential disorder. When applied to the dorsolateral prefrontal cortex (DLPFC), repetitive transcranial magnetic stimulation (rTMS) reduces craving across substance use disorders and may have therapeutic clinical effects when applied in serial-sessions. The present study sought to preliminarily determine whether serial-sessions of rTMS applied to the DLPFC had a therapeutic effect in CUD.
methodsThis study was a two-site, phase-2, double-blind, randomized-controlled-trial. Seventy-two treatment-seeking participants (37.5% Women, mean age 30.2±9.9SD) with ≥moderate-CUD were randomized to active or sham rTMS (Beam-F3, 10Hz, 20-total-sessions, two-sessions-per-visit, two-visits-per-week, with cannabis cues) while undergoing a three-session motivational enhancement therapy intervention. The primary outcome was the change in craving between pre- and post- treatment (Marijuana Craving Questionnaire Short-Form-MCQ-SF). Secondary outcomes included the number of weeks of abstinence and the number of days-per-week of cannabis use during 4-weeks of follow-up.
resultsThere were no significant differences in craving between conditions. Participants who received active-rTMS reported numerically, but not significantly, more weeks of abstinence in the follow-up period than those who received sham-rTMS (15.5%-Active; 9.3%-Sham; rate ratio = 1.66 [95% CI: 0.84, 3.28]; p=0.14). Participants who received active-rTMS reported fewer days-per-week of cannabis use over the final two-weeks of the follow-up period than those receiving sham-rTMS (Active vs. Sham: -0.72; Z=-2.33, p=0.02).
conclusionsThis trial suggests rTMS is safe and feasible in individuals with CUD and may have a therapeutic effect on frequency of cannabis use, though further study is needed with additional rTMS-sessions and a longer follow-up period.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.