Evidence map›Paper›PMID 38043128›Full record

SynthesisEuropean spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society2024

Clinical effectiveness of reduction and fusion versus in situ fusion in the management of degenerative lumbar spondylolisthesis: a systematic review and meta-analysis.

Dongfan Wang, Wei Wang, Di Han, Sathish Muthu, Juan P Cabrera, Waeel Hamouda, Luca Ambrosio, Jason P Y Cheung, Hai V Le, Gianluca Vadalà and 8 more

Abstract readSystematic ReviewMeta-Analysis
PubMed Publisher
In one paragraph

Synthesis in European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Dongfan WangDepartment of Orthopedics, Xuanwu Hospital, Capital Medical University, No.45 Changchun Street, Xicheng District, Beijing, China.ORCID 0000-0003-2869-3809
Wei WangDepartment of Orthopedics, Xuanwu Hospital, Capital Medical University, No.45 Changchun Street, Xicheng District, Beijing, China.
Di HanDepartment of Orthopedics, Xuanwu Hospital, Capital Medical University, No.45 Changchun Street, Xicheng District, Beijing, China.
Sathish MuthuOrthopaedic Research Group, Coimbatore, Tamil Nadu, India.
Juan P CabreraDepartment of Neurosurgery, Hospital Clínico Regional de Concepción, Concepción, Chile.
Waeel HamoudaDepartment of Neurosurgery, Kasr Alainy Faculty of Medicine, Research and Teaching Hospitals, Cairo University, Cairo, Egypt.
Luca AmbrosioOperative Research Unit of Orthopaedic and Trauma Surgery, Fondazione Policlinico Universitario Campus Bio-Medico, Rome, Italy.
Jason P Y CheungDepartment of Orthopaedics and Traumatology, The University of Hong Kong, Hong Kong SAR, China.
Hai V LeDepartment of Orthopaedic Surgery, University of California, Davis, CA, USA.
Gianluca VadalàOperative Research Unit of Orthopaedic and Trauma Surgery, Fondazione Policlinico Universitario Campus Bio-Medico, Rome, Italy.
Zorica BuserDepartment of Orthopedic Surgery, NYU Grossman School of Medicine, New York, NY, USA.
Jeffrey C WangDepartment of Orthopaedic Surgery and Neurological Surgery, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Samuel ChoDepartment of Orthopedic Surgery, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
S Tim YoonDepartment of Orthopaedics, Emory University, Atlanta, GA, USA.
Shibao LuDepartment of Orthopedics, Xuanwu Hospital, Capital Medical University, No.45 Changchun Street, Xicheng District, Beijing, China. spinelu@163.com.ORCID 0000-0002-6508-4458
Xiaolong ChenDepartment of Orthopedics, Xuanwu Hospital, Capital Medical University, No.45 Changchun Street, Xicheng District, Beijing, China. chensmalldragon@163.com.
Ashish D DiwanSpine Service, Department of Orthopaedic Surgery, St. George Hospital Campus, Sydney, NSW, Australia. a.diwan@spine-service.org.
AO Spine Knowledge Forum Degenerative

Funding

Beijing Hospitals Authority Ascent Plan DFL20190802Beijing Hospitals Authority Clinical Medicine Development of special funding support XMLX202116
6 · The paper itself

Abstract

purposeTo compare the clinical effectiveness of reduction and fusion with in situ fusion in the management of patients with degenerative lumbar spondylolisthesis (DLS).

methodsThe systematic review was conducted following the PRISMA guidelines. Relevant studies were identified from PubMed, Embase, Scopus, Cochrane Library, ClinicalTrials.gov, and Google Scholar. The inclusion criteria were: (1) comparative studies of reduction and fusion versus in situ fusion for DLS patients, (2) outcomes reported as VAS/NRS, ODI, JOA score, operating time, blood loss, complication rate, fusion rate, or reoperation rate, (3) randomized controlled trials and observational studies published in English from the inception of the databases to January 2023. The exclusion criteria included: (1) reviews, case series, case reports, letters, and conference reports, (2) in vitro biomechanical studies and computational modeling studies, (3) no report on study outcomes. The risk of bias 2 (RoB2) tool and the Newcastle-Ottawa scale was conducted to assess the risk of bias of RCTs and observational studies, respectively.

resultsFive studies with a total of 704 patients were included (375 reduction and fusion, 329 in situ fusion). Operating time was significantly longer in the reduction and fusion group compared to in situ fusion group (weighted mean difference 7.20; 95% confidence interval 0.19, 14.21; P = 0.04). No additional significant intergroup differences were noted in terms of other outcomes analyzed.

conclusionWhile the reduction and fusion group demonstrated a statistically longer operating time compared to the in situ fusion group, the clinical significance of this difference was minimal. The findings suggest no substantial superiority of lumbar fusion with reduction over without reduction for the management of DLS.

Indexed as

Lumbar VertebraeSpinal FusionSpondylolisthesisHumansTreatment OutcomeDegenerative spondylolisthesisIn situ fusionLumbar spineMeta-analysisReduction and fusionReview

Identifiers

PMID38043128

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.