Evidence map›Paper›PMID 38043041›Full record

ArticleThe Journal of adolescent health : official publication of the Society for Adolescent Medicine2024

Demographics of Youth With Newly Diagnosed Acute/Recent HIV Infection in Adolescent Trials Network 147: Early Treatment of Acute HIV Infection.

Tara Kerin, Ruth Cortado, Sophia G Paiola, Justine Ceballos, Sue Ellen Abdalian, Risa Flynn, Robert Bolan, Yetunde V Adebambo, Myung Shin Sim, Dallas Swendeman and 5 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of adolescent health : official publication of the Society for Adolescent Medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.4field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 2 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 3 institutions in 1 country.

Tara KerinDepartment of Pediatrics, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California. Electronic address: tkerin@mednet.ucla.edu.
Ruth CortadoDepartment of Pediatrics, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California.
Sophia G PaiolaDepartment of Pediatrics, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California.
Justine CeballosDepartment of Pediatrics, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California.
Sue Ellen AbdalianDepartment of Pediatrics, School of Medicine, Tulane University, New Orleans, Louisiana.
Risa FlynnThe Los Angeles LGBT Center, Los Angeles, California.
Robert BolanThe Los Angeles LGBT Center, Los Angeles, California.
Yetunde V AdebamboUCLA Department of Medicine Statistics Core, University of California Los Angeles, Los Angeles, California.
Myung Shin SimUCLA Department of Medicine Statistics Core, University of California Los Angeles, Los Angeles, California.
Dallas SwendemanDepartment of Psychiatry and Behavioral Sciences, University of California Los Angeles, Los Angeles, California.
Manuel A OcasioDepartment of Pediatrics, School of Medicine, Tulane University, New Orleans, Louisiana.
Jasmine FournierDepartment of Pediatrics, School of Medicine, Tulane University, New Orleans, Louisiana.
Bonnie AnkDepartment of Pediatrics, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California.
Yvonne BrysonDepartment of Pediatrics, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California.
Karin Nielsen-SainesDepartment of Pediatrics, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California.
University of California, Los Angeles · USTulane University · USLos Angeles LGBT Center · US

Funding

UCLA Rapid, Relevant, Rigorous Implementation Science HubP30MH058107 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Sung-Jae Lee · 1997 to 2026
$53.5M
Optimizing the HIV Treatment Continuum with a Stepped Care Model for Youth Living with HIVU19HD089886 · NICHD · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI FERNANDEZ, MARIA ISABEL, ROTHERAM-BORUS, MARY JANE · 2016 to 2022
$23.4M
NICHD NIH HHS U19 HD089886NIMH NIH HHS P30 MH058107
6 · The paper itself

Abstract

purposeGay, bisexual, and other cisgender men who have sex with men, and racial minority youth are at elevated risk of acquiring HIV infection. The Adolescent Trials Network 147 recruited youth with acute/recent HIV-infection for early antiretroviral treatment. The cohort make-up is described here.

methodsTreatment-naïve, recently identified HIV + youth, aged 12-24 years, from Los Angeles and New Orleans were recruited from community centers, clinics, social media, and a high-risk seronegative cohort (n = 1,727, the Adolescent Trials Network 149) using point-of-care assays. Acute HIV infection was determined by Fiebig staging. HIV RNA viral load (VL) and CD4 cell counts, along with demographic and behavioral data were assessed at enrollment.

resultsBetween July 2017 and July 2021, 103 newly diagnosed youth were enrolled, initiating antiretroviral treatment within a week. Mean age was 20.8 years (standard deviation: 2.4); 90.3% identified as cis male, 83.5% were single or in casual relationships, 71.8% were gay, bisexual, and other cisgender men who have sex with men; 60.2% were Black. One-fourth (24.3%) reported homelessness ever; 10.7% within last 4 months. At enrollment, median plasma VL was 37,313 HIV RNA copies/ml (interquartile range: 5,849-126,162) and median CD4 count 445.5 cells/mm3 (interquartile range: 357-613). 40% of youth reported acute retroviral symptoms before or at enrollment. Acutely infected, seroconverting youth had the highest VL. Sexually transmitted coinfections were present at enrollment in 56% of the cohort, with syphilis being most frequent (39%). DISCUSSION: Early identification and treatment of HIV can increase positive HIV outcomes. A high sexually transmitted infection burden was present in recently HIV-infected youth. Acute retroviral symptoms were not reported by most participants, demonstrating that broad universal HIV screening is needed for identification of recent infection in youth.

Indexed as

HIV InfectionsSexual and Gender MinoritiesAdolescentAdultCD4 Lymphocyte CountDemographyHomosexuality, MaleHumansMaleRNAViral LoadYoung AdultRNAAcute HIV infectionHIVyouth HIV

Identifiers

PMID38043041
PMCPMC10840998
OpenAlexW4389283850

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.