Evidence map›Paper›PMID 38042946›Full record

ArticlePediatric research2024

Antenatal jaundice instruction and acute bilirubin encephalopathy in Nigeria.

Richard P Wennberg, Zainab O Imam, David D Shwe, Laila Hassan, Zubaida L Farouk, Lindsey E Turner, Ann M Brearley, Tina M Slusher, Stephen Oguche

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pediatric research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
2.3field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 4 citations in OpenAlex.

  1. Trial
  2. Trial
  3. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 7 institutions in 2 countries.

Richard P WennbergEmeritus, Department of Pediatrics, University of California, Davis, Davis, CA, USA. rpw3450@gmail.com.
Zainab O ImamDepartment of Pediatrics, Lagos State University Teaching Hospital, Lagos, Nigeria.
David D ShweDepartment of Pediatrics, University of Jos, Jos, Nigeria.
Laila HassanDepartment of Pediatrics, Ahmadu Bello University, Zaria, Nigeria.
Zubaida L FaroukDepartment of Pediatrics, Bayero University, Kano, Nigeria.
Lindsey E TurnerDivision of Biostatistics, School of Public Health, University of Minnesota, Minneapolis, MN, USA.
Ann M BrearleyDivision of Biostatistics, School of Public Health, University of Minnesota, Minneapolis, MN, USA.
Tina M Slusher *Department of Pediatrics, University of Minnesota, Minneapolis, MN, USA.
Stephen Oguche *Department of Pediatrics, University of Jos, Jos, Nigeria.
University of Jos · NGUniversity of Minnesota · USAhmadu Bello University · NGBayero University Kano · NGHennepin Healthcare Research Institute · USLagos State University Teaching Hospital · NGUniversity of California, Davis · US

Funding

University of Minnesota Clinical and Translational Science Institute (UMN CTSI)UL1TR002494 · NCATS · UNIVERSITY OF MINNESOTA · PI BLAZAR, BRUCE R, WEISDORF, DANIEL J · 2018 to 2022
$34.9M
NCATS NIH HHS UL1 TR002494
6 · The paper itself

Abstract

backgroundAcute Bilirubin Encephalopathy (ABE) is common in Nigeria. Parents' inability to recognize jaundice and delays in seeking care are significant barriers to its prevention.

methodsWe compared associations of (1) interactive antenatal maternal jaundice instruction with postnatal reinforcement, (2) standard postnatal instruction, and (3) no maternal instruction with the incidence of ABE among 647 jaundice admissions stratified for risk factors identified in initial descriptive analysis.

resultsEighty-three (83/647;12.8%) admissions developed ABE including eleven jaundice-related deaths. ABE was present at admission in 20/22 (90.9%) if mothers received no jaundice instruction and no antenatal care, 42/182 (23.1%) if received antenatal care but no instruction, 16/95 (16.8%) if received postnatal instruction only, and 4/337 (1.2%) if mothers received both antenatal and postnatal instruction (p < .001). ABE was highly associated with out-of-hospital delivery, number of antenatal clinic visits, and birth attendant, but these risks were mitigated by antenatal/postnatal instruction. Admission rates with bilirubin levels below treatment guidelines (12 mg/dL) were higher following instruction (30.7%) than with no instruction (14.4%). Limiting subjects to those meeting admission criteria increased ABE rates in all groups without altering conclusions.

conclusionInteractive antenatal instruction with postnatal reinforcement resulted in timely care seeking and a lower incidence of ABE. IMPACT: Empowering mothers to participate in neonatal jaundice management is critical in low-income countries where jaundice monitoring and follow up are unreliable. Instructing mothers about jaundice in antenatal clinics with postnatal reinforcement is more effective than standard postpartum instruction in facilitating jaundice detection, timely care seeking, and lowering the incidence of acute bilirubin encephalopathy (ABE). Antenatal training also mitigates risks for ABE associated with out-of-hospital deliveries, limited antenatal care, and unskilled birth attendants. IMPACT: Adding structured jaundice instruction in antenatal clinics could greatly reduce bilirubin induced brain injury in countries where ABE is common.

Indexed as

Jaundice, NeonatalKernicterusPrenatal CareAcute DiseaseAdultBilirubinFemaleHumansIncidenceInfant, NewbornMaleNigeriaPregnancyRisk FactorsBilirubin

Identifiers

PMID38042946
PMCPMC11035125
OpenAlexW4389267627

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.