ArticleInternational journal of obesity (2005)2024
Conversions between metabolically unhealthy and healthy obesity from midlife to late-life.
Article in International journal of obesity (2005), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 21 citations in OpenAlex.
- Article
- Senescent obesity signature in breast cancer: a paradigm of reverse cardio-oncology.European heart journal · 2026Review
- Dementia risk by metabolic health and obesity in two prospective cohorts.BMC medicine · 2026Article
- Review
- Dynamic associations of BMI-metabolic phenotype transitions with incident cardiovascular disease in middle-aged and elderly adults: a longitudinal cohort study.BMC cardiovascular disorders · 2026Article
- Article
- Body Adiposity Indices, Adipokines Profile, and CNR1 Polymorphisms in Atypical Phenotypes of Obesity.Metabolites · 2026Article
- Suppression of adipocyte ABHD6 favors anti-inflammatory and adipogenic programs to preserve adipose tissue fitness in obesity.Molecular metabolism · 2025Article
- Clinical Heterogeneity and Transitions of Obesity in Mexico.The Journal of clinical endocrinology and metabolism · 2025Article
- Different Metabolic Phenotypes of Obesity and 2 Decades Risk of Cardio-Renal-Metabolic Multimorbidity: Tehran Lipid and Glucose Study.Journal of the American Heart Association · 2025Article
- Article
- Assessment of the Risk of Insulin Resistance in Workers Classified as Metabolically Healthy Obese.Nutrients · 2025Article
- Metabolically unhealthy adipose tissue is characterized by reductions in mitochondrial size and function.Obesity (Silver Spring, Md.) · 2025Article
- Circulating hs-CRP, IL-18, Chemerin, Leptin, and Adiponectin Levels Reflect Cardiometabolic Dysfunction in Adults with Excess Weight.International journal of molecular sciences · 2025Article
- Identifying obesity and dementia risk: body adiposity and neural connectivity in cognitively normal, mid-life adults.NPJ dementia · 2025Article
- How is the brain affected by metabolically healthy or unhealthy obesity in adulthood and elderly? A narrative review of neuroimaging and neurocognitive findings.Frontiers in aging neuroscience · 2025Review
- Reverse epidemiology of obesity paradox: Fact or fiction?Physiological reports · 2024Review
- Metabolic obesity phenotypes and all-cause mortality among the Chinese oldest-old population: a prospective cohort study.International journal of obesity (2005) · 2024Article
Corrections and comments
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Authors and funding
6 authors at 4 institutions in 3 countries.
Funding
Abstract
introductionMetabolically healthy obesity may be a transient phenotype, but studies with long follow-up, especially covering late-life, are lacking. We describe conversions between cross-categories of body mass index (BMI) and metabolic health in 786 Swedish twins with up to 27 years of follow-up, from midlife to late-life.
methodsMetabolic health was defined as the absence of metabolic syndrome (MetS). We first visualized conversions between BMI-metabolic health phenotypes in 100 individuals with measurements available at ages 50-64, 65-79, and ≥80. Next, we modeled conversion in metabolic health status by BMI category in the full sample using Cox proportional hazards regression.
resultsThe proportion of individuals with MetS and with overweight or obesity increased with age. However, one-fifth maintained a metabolically healthy overweight or obesity across all three age categories. Among those metabolically healthy at baseline, 59% converted to MetS during follow-up. Conversions occurred 56% more often among individuals with metabolically healthy obesity, but not overweight, compared to normal weight. Among those with MetS at baseline, 60% regained metabolic health during follow-up, with no difference between BMI categories.
conclusionsConversions between metabolically healthy and unhealthy status occurred in both directions in all BMI categories. While conversions to MetS were more common among individuals with obesity, many individuals maintained or regained metabolic health during follow-up.
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