Evidence map›Paper›PMID 38042929›Full record

ArticleNature communications2023

Role of PDGFRA

Elisa Manieri, Guodong Tie, Ermanno Malagola, Davide Seruggia, Shariq Madha, Adrianna Maglieri, Kun Huang, Yuko Fujiwara, Kevin Zhang, Stuart H Orkin and 4 more

Open access · goldAbstract read
In one paragraph

Article in Nature communications, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
3.7field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 16 citations in OpenAlex.

  1. Article
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  9. Roles of PDGF/PDGFR signaling in various organs.The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology · 2025
    Review
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

14 authors at 4 institutions in 2 countries.

Elisa ManieriDepartment of Medical Oncology and Center for Functional Cancer Epigenetics, Dana-Farber Cancer Institute, Boston, MA, 02215, USA.ORCID 0000-0002-7525-019X
Guodong TieDepartment of Medical Oncology and Center for Functional Cancer Epigenetics, Dana-Farber Cancer Institute, Boston, MA, 02215, USA.
Ermanno MalagolaDivision of Digestive and Liver Diseases, Department of Medicine and Irving Cancer Research Center, Columbia University Medical Center, New York, NY, 10032, USA.ORCID 0000-0001-9294-3097
Davide SeruggiaDepartment of Hematology, Boston Children's Hospital, Boston, MA, 02115, USA.ORCID 0000-0001-5014-0499
Shariq MadhaDepartment of Medical Oncology and Center for Functional Cancer Epigenetics, Dana-Farber Cancer Institute, Boston, MA, 02215, USA.
Adrianna MaglieriDepartment of Medical Oncology and Center for Functional Cancer Epigenetics, Dana-Farber Cancer Institute, Boston, MA, 02215, USA.ORCID 0000-0002-4096-2306
Kun HuangMolecular Imaging Core and Department of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Boston, MA, 02215, USA.ORCID 0000-0002-9100-9638
Yuko FujiwaraDepartment of Hematology, Boston Children's Hospital, Boston, MA, 02115, USA.
Kevin ZhangDepartment of Hematology, Boston Children's Hospital, Boston, MA, 02115, USA.
Stuart H OrkinDepartment of Hematology, Boston Children's Hospital, Boston, MA, 02115, USA.ORCID 0000-0002-0313-152X
Timothy C WangDivision of Digestive and Liver Diseases, Department of Medicine and Irving Cancer Research Center, Columbia University Medical Center, New York, NY, 10032, USA.
Ruiyang HeDepartment of Medical Oncology and Center for Functional Cancer Epigenetics, Dana-Farber Cancer Institute, Boston, MA, 02215, USA.
Neil McCarthyDepartment of Medical Oncology and Center for Functional Cancer Epigenetics, Dana-Farber Cancer Institute, Boston, MA, 02215, USA.ORCID 0000-0001-6021-1369
Ramesh A ShivdasaniDepartment of Medical Oncology and Center for Functional Cancer Epigenetics, Dana-Farber Cancer Institute, Boston, MA, 02215, USA. ramesh_shivdasani@dfci.harvard.edu.ORCID 0000-0002-2828-1727
Dana-Farber Cancer Institute · USBoston Children's Hospital · USHarvard University · USColumbia University Irving Medical Center · US

Funding

The Role of Stem Cells and the Microenvironment in Gastrointestinal CancersR35CA210088 · NCI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI Timothy Cragin Wang · 2017 to 2026
$10.2M
Gastroesophageal junction stem cells as the origin of Barretts esophagus and cancerR01CA272901 · NCI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI QUE, JIANWEN, WANG, TIMOTHY CRAGIN · 2022 to 2025
$4.9M
Understanding stem cell heterogeneity and niche function in intestinal regeneration after irradiationU01DK103155 · NIDDK · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI GUHA, CHANDAN, WANG, TIMOTHY CRAGIN · 2014 to 2023
$4.4M
Chromatin and transcriptional control of LGR5+ crypt base stem cellsU01DK103152 · NIDDK · DANA-FARBER CANCER INST · PI SHIVDASANI, RAMESH A · 2014 to 2023
$4.2M
Development and vascularity of intestinal mesenchymeR01DK121540 · NIDDK · DANA-FARBER CANCER INST · PI Ramesh A Shivdasani · 2019 to 2026
$3.3M
Mesenchymal regulation of fetal intestinal development and adult regenerationK01DK125639 · NIDDK · NORTH CAROLINA STATE UNIVERSITY RALEIGH · PI MCCARTHY, NEIL · 2020 to 2024
$692k
NCI NIH HHS R01 CA272901NCI NIH HHS R35 CA210088NIDDK NIH HHS K01 DK125639NIDDK NIH HHS R01 DK121540NIDDK NIH HHS U01 DK103152NIDDK NIH HHS U01 DK103155
6 · The paper itself

Abstract

PDGFRA-expressing mesenchyme supports intestinal stem cells. Stomach epithelia have related niche dependencies, but their enabling mesenchymal cell populations are unknown, in part because previous studies pooled the gastric antrum and corpus. Our high-resolution imaging, transcriptional profiling, and organoid assays identify regional subpopulations and supportive capacities of purified mouse corpus and antral PDGFRA

Indexed as

Gastric MucosaStomachAnimalsEpithelial CellsIntestinesMicePyloric AntrumReceptor Protein-Tyrosine KinasesStem CellsReceptor Protein-Tyrosine Kinases

Identifiers

PMID38042929
PMCPMC10693581
OpenAlexW4389266189

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.