ArticleScientific reports2023
High frequency oscillations in relation to interictal spikes in predicting postsurgical seizure freedom.
Article in Scientific reports, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- Inroads into epilepsy through high-frequency oscillations: Achievements and benchmark areas for improvement.Epilepsia · 2026Review
- Spike-fast activity interplay: A gateway to seizure.Epilepsia · 2026Article
- Multicentre analysis of seizure outcome predicted by removal of high-frequency oscillations.Brain : a journal of neurology · 2025Observational
- Implementing intraoperative high-density electrocorticography during epilepsy surgery.Epilepsia · 2025Article
- Non-Invasive Localization of Epileptogenic Zone in Drug-Resistant Epilepsy Based on Time-Frequency Analysis and VGG Convolutional Neural Network.Bioengineering (Basel, Switzerland) · 2025Article
- Automated Detection of Aberrant Episodes in Epileptic Conditions: Leveraging EEG and Machine Learning Algorithms.Bioengineering (Basel, Switzerland) · 2025Article
- Mapping the Epileptogenic Brain Using Low-Frequency Stimulation: Two Decades of Advances and Uncertainties.Journal of clinical medicine · 2025Review
- Normative high-frequency oscillation phase-amplitude coupling and effective connectivity under sevoflurane.Brain communications · 2025Article
- Spikes on ripples are better interictal biomarkers of epilepsy than spikes or ripples.Brain communications · 2025Article
- Electroencephalographic source imaging of spikes with concurrent high-frequency oscillations is concordant with the clinical ground truth.Epilepsia · 2024Article
- Overlap of spike and ripple propagation onset predicts surgical outcome in epilepsy.Annals of clinical and translational neurology · 2024Article
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Authors and funding
5 authors.
Funding
Abstract
We evaluate whether interictal spikes, epileptiform HFOs and their co-occurrence (Spike + HFO) were included in the resection area with respect to seizure outcome. We also characterise the relationship between high frequency oscillations (HFOs) and propagating spikes. We analysed intracranial EEG of 20 patients that underwent resective epilepsy surgery. The co-occurrence of ripples and fast ripples was considered an HFO event; the co-occurrence of an interictal spike and HFO was considered a Spike + HFO event. HFO distribution and spike onset were compared in cases of spike propagation. Accuracy in predicting seizure outcome was 85% for HFO, 60% for Spikes, and 79% for Spike + HFO. Sensitivity was 57% for HFO, 71% for Spikes and 67% for Spikes + HFO. Specificity was 100% for HFO, 54% for Spikes and 85% for Spikes + HFO. In 2/2 patients with spike propagation, the spike onset included the HFO area. Combining interictal spikes with HFO had comparable accuracy to HFO. In patients with propagating spikes, HFO rate was maximal at the onset of spike propagation.
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