Evidence map›Paper›PMID 38042919›Full record

ArticleNPJ digital medicine2023

A medical multimodal large language model for future pandemics.

Fenglin Liu, Tingting Zhu, Xian Wu, Bang Yang, Chenyu You, Chenyang Wang, Lei Lu, Zhangdaihong Liu, Yefeng Zheng, Xu Sun and 3 more

Abstract read
In one paragraph

Article in NPJ digital medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 55 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
55citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

55 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Review
  5. Article
  6. Review
  7. A comprehensive survey of AI agents in healthcare.Journal of biomedical informatics · 2026
    Review
  8. Review
  9. Article
  10. Rethinking Ethics for an Era of Trusted Computational Tools.The Psychiatric clinics of North America · 2026
    Review
  11. Article
  12. Review
  13. Article
  14. Article
  15. Domain-adapted language model using reinforcement learning for various dementias.medRxiv : the preprint server for health sciences · 2026
    Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Fenglin LiuInstitute of Biomedical Engineering, Department of Engineering Science, University of Oxford, Oxford, UK. fenglin.liu@eng.ox.ac.uk.ORCID http://orcid.org/0000-0001-7715-5228
Tingting ZhuInstitute of Biomedical Engineering, Department of Engineering Science, University of Oxford, Oxford, UK.ORCID http://orcid.org/0000-0002-1552-5630
Xian WuJarvis Research Center, Tencent YouTu Lab, Beijing, China.
Bang YangSchool of Computer Science, Peking University, Beijing, China.ORCID http://orcid.org/0000-0003-2019-0377
Chenyu YouYale University, New Haven, CT, USA.ORCID http://orcid.org/0000-0001-8365-7822
Chenyang WangInstitute of Biomedical Engineering, Department of Engineering Science, University of Oxford, Oxford, UK.ORCID http://orcid.org/0000-0003-1851-9866
Lei LuInstitute of Biomedical Engineering, Department of Engineering Science, University of Oxford, Oxford, UK.
Zhangdaihong LiuInstitute of Biomedical Engineering, Department of Engineering Science, University of Oxford, Oxford, UK.
Yefeng ZhengJarvis Research Center, Tencent YouTu Lab, Beijing, China.ORCID http://orcid.org/0000-0003-2195-2847
Xu SunSchool of Computer Science, Peking University, Beijing, China.
Yang YangSchool of Public Health, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Lei CliftonNuffield Department of Population Health, University of Oxford, Oxford, UK.
David A CliftonInstitute of Biomedical Engineering, Department of Engineering Science, University of Oxford, Oxford, UK. david.clifton@eng.ox.ac.uk.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Deep neural networks have been integrated into the whole clinical decision procedure which can improve the efficiency of diagnosis and alleviate the heavy workload of physicians. Since most neural networks are supervised, their performance heavily depends on the volume and quality of available labels. However, few such labels exist for rare diseases (e.g., new pandemics). Here we report a medical multimodal large language model (Med-MLLM) for radiograph representation learning, which can learn broad medical knowledge (e.g., image understanding, text semantics, and clinical phenotypes) from unlabelled data. As a result, when encountering a rare disease, our Med-MLLM can be rapidly deployed and easily adapted to them with limited labels. Furthermore, our model supports medical data across visual modality (e.g., chest X-ray and CT) and textual modality (e.g., medical report and free-text clinical note); therefore, it can be used for clinical tasks that involve both visual and textual data. We demonstrate the effectiveness of our Med-MLLM by showing how it would perform using the COVID-19 pandemic "in replay". In the retrospective setting, we test the model on the early COVID-19 datasets; and in the prospective setting, we test the model on the new variant COVID-19-Omicron. The experiments are conducted on 1) three kinds of input data; 2) three kinds of downstream tasks, including disease reporting, diagnosis, and prognosis; 3) five COVID-19 datasets; and 4) three different languages, including English, Chinese, and Spanish. All experiments show that our model can make accurate and robust COVID-19 decision-support with little labelled data.

Identifiers

PMID38042919
PMCPMC10693607

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.