SynthesisCritical care (London, England)2023
Prognostic value of capillary refill time in adult patients: a systematic review with meta-analysis.
Synthesis in Critical care (London, England), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 26 citations in OpenAlex.
- Persistent tissue hypoperfusion improves risk stratification beyond vasopressor dose in refractory septic shock: a secondary analysis of the ANDROMEDA-SHOCK-2 trial.Intensive care medicine · 2026Trial
- The usual suspects: a pragmatic framework to identify and address reversible contributors in apparent refractory septic shock.Critical care (London, England) · 2026Review
- Beyond blood pressure: a comprehensive overview of clinical indices in shock and tissue hypoperfusion.Acute and critical care · 2026Article
- Passive leg raising, peripheral perfusion, and cardiac output: insights into hemodynamic coherence.Critical care (London, England) · 2026Article
- Impaired tissue perfusion in high-risk patients having major abdominal surgery: a multicenter observational study.Critical care (London, England) · 2026Observational
- Resuscitation Targets, Fluids, and Vasoactives in Septic Shock.Clinics in chest medicine · 2026Review
- Comparison of four noninvasive tools for predicting sepsis and septic shock mortality: a prospective cohort study.Clinical and experimental emergency medicine · 2026Article
- Device-measured capillary refill time identifies critically ill cases in the emergency department.Scientific reports · 2026Observational
- DiCARTJournal of clinical monitoring and computing · 2025Article
- Serum Levels of 54 Cytokines and Chemokines Reveal Distinct Inflammatory Signatures in Ankylosing Spondylitis.Immunity, inflammation and disease · 2025Article
- The intricate relationship between capillary refill time and systemic hemodynamics in septic shock.Annals of intensive care · 2025Review
- The Predictive Value of Clinical Signs to Identify Shock in Critically Ill Patients.Diagnostics (Basel, Switzerland) · 2025Article
- Gingival capillary refill time: a new approach to assess tissue perfusion.Critical care (London, England) · 2025Article
- Point of View: A Holistic Four-Interface Conceptual Model for Personalizing Shock Resuscitation.Journal of personalized medicine · 2025Review
- Relationship between point-of-care ultrasound venous congestion assessment parameters, intravenous pressure, and venous return: a post-hoc analysis of a prospective cohort study.The ultrasound journal · 2025Article
- Changes in portal pulsatility index induced by a fluid challenge in patients with haemodynamic instability and systemic venous congestion: a prospective cohort study.Annals of intensive care · 2024Article
- Treatment of Acute Kidney Injury: A Review of Current Approaches and Emerging Innovations.Journal of clinical medicine · 2024Review
- The Role of Microcirculation in Haemodynamics: A Journey from Atlas to Sisyphus.Journal of critical care medicine (Universitatea de Medicina si Farmacie din Targu-Mures) · 2024Article
- Capillary refill time response to a fluid challenge or a vasopressor test: an observational, proof-of-concept study.Annals of intensive care · 2024Article
- The use of thermal imaging for evaluation of peripheral tissue perfusion in surgical patients with septic shock.BMC anesthesiology · 2024Observational
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 6 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeAcute circulatory failure leads to tissue hypoperfusion. Capillary refill time (CRT) has been widely studied, but its predictive value remains debated. We conducted a meta-analysis to assess the ability of CRT to predict death or adverse events in a context at risk or confirmed acute circulatory failure in adults.
methodMEDLINE, EMBASE, and Google scholar databases were screened for relevant studies. The pooled area under the ROC curve (AUC ROC), sensitivity, specificity, threshold, and diagnostic odds ratio using a random-effects model were determined. The primary analysis was the ability of abnormal CRT to predict death in patients with acute circulatory failure. Secondary analysis included the ability of CRT to predict death or adverse events in patients at risk or with confirmed acute circulatory failure, the comparison with lactate, and the identification of explanatory factors associated with better accuracy.
resultsA total of 60,656 patients in 23 studies were included. Concerning the primary analysis, the pooled AUC ROC of 13 studies was 0.66 (95%CI [0.59; 0.76]), and pooled sensitivity was 54% (95%CI [43; 64]). The pooled specificity was 72% (95%CI [55; 84]). The pooled diagnostic odds ratio was 3.4 (95%CI [1.4; 8.3]). Concerning the secondary analysis, the pooled AUC ROC of 23 studies was 0.69 (95%CI [0.65; 0.74]). The prognostic value of CRT compared to lactate was not significantly different. High-quality CRT was associated with a greater accuracy.
conclusionCRT poorly predicted death and adverse events in patients at risk or established acute circulatory failure. Its accuracy is greater when high-quality CRT measurement is performed.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.