SynthesisBMC infectious diseases2023
Pooled prevalence of lymphopenia in all-cause hospitalisations and association with infection: a systematic review and meta-analysis.
Synthesis in BMC infectious diseases, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 14 citations in OpenAlex.
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- Pretreatment neutrophil-to-lymphocyte ratio (NLR) as a potential risk marker for febrile neutropenia (FN) in breast and ovarian cancer during first-cycle chemotherapy.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2026Article
- Prognostic nutritional index and long-term outcomes after coronary artery bypass grafting.BMC surgery · 2026Article
- High-density lipoprotein-related inflammatory markers and their association with all-cause and cardiovascular mortality in an ageing population: findings from a prospective cohort study based on NHANES data.Journal of global health · 2026Article
- Adenosine signaling promotes double-negative T-cell anticancer responses in conditions of CD8 T-cell lymphopenia.Blood immunology & cellular therapy · 2026Article
- Impact of lymphopenia and hypogammaglobulinemia on outcomes in neutropenic patients with hematological malignancies.International journal of hematology · 2026Article
- Immune dysregulation through longitudinal lymphocyte trajectories and their clinical determinants in hospitalized COVID-19 patients.Intensive care medicine experimental · 2026Article
- Improved prediction value of the CURB-65 score combined with the platelet-to-lymphocyte ratio for mortality in emergency department patients with severe community-acquired pneumonia.Frontiers in medicine · 2026Article
- Early systemic immune-inflammation index is associated with mortality and functional outcome in brainstem hemorrhage.Frontiers in neurology · 2026Article
- The association between white blood cell-to-hemoglobin ratio and mortality risk in critical traumatic brain injury: insights from MIMIC-IV retrospective analysis.European journal of medical research · 2025Article
- Time series modeling shows early lymphocyte decline predicts inflammatory rise and mortality in older adults with community acquired pneumonia.Scientific reports · 2025Article
- Association Between Platelet-to-Lymphocyte Ratio and Insulin Resistance in Cancer Survivors: A Cross-Sectional Study Based on the NHANES 2005 - 2018.World journal of oncology · 2025Article
- Acute Respiratory Distress Syndrome in Patients with Lymphopenia: Results from the National Inpatient Sample (2017-2021).Journal of clinical medicine · 2025Article
- Pharmacological and genetic inhibition of ARG2 in CXCR2Theranostics · 2025Article
- Living with a transplanted liver is associated with cytopenias: a nationwide cohort study.Frontiers in gastroenterology (Lausanne, Switzerland) · 2025Article
- Sterile Inflammatory Response and Surgery-Related Trauma in Elderly Patients with Subtrochanteric Fractures.Biomedicines · 2024Article
- Key differences between chronic inducible and spontaneous urticaria.Frontiers in allergy · 2024Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundLymphopenia is defined as a decrease below normal value (often 1.0 x 10
methodsPeer-reviewed search strategy was performed on three databases. Primary objective was to summarise the pooled prevalence of lymphopenia. Primary outcome was infection including pre-existing lymphopenia as a risk factor for admission with infection and as an in-hospital risk factor for healthcare-associated infection. Secondary outcomes were length of stay and mortality. Mortality data extracted included in-hospital, 28/30-day ('early'), and 90-day/1-year ('late') mortality. Meta-analysis was carried out using random-effects models for each outcome measure. Heterogeneity was assessed using I
resultsFifteen observational studies were included. The pooled prevalence of lymphopenia in all-cause hospitalisations was 38% (CI 0.34-0.42, I
conclusionsThis meta-analysis demonstrates the high prevalence of lymphopenia across all-cause hospitalisations and associated increased risk of septic shock, early and late mortality. Lymphopenia is a readily available marker that may identify immune dysfunctional patients. Greater understanding of immune trajectories following survival may provide insights into longer-term poor clinical outcomes.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.