Evidence map›Paper›PMID 38042775›Full record

ArticleJournal of neuroinflammation2023

Astrocyte-specific knockout of YKL-40/Chi3l1 reduces Aβ burden and restores memory functions in 5xFAD mice.

Xiaoyan Zeng, Stanley K K Cheung, Mengqi Shi, Penelope M Y Or, Zhining Li, Julia Y H Liu, Wayne L H Ho, Tian Liu, Kun Lu, John A Rudd and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of neuroinflammation, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Review
  4. Article
  5. Article
  6. Article
  7. Mercury-induced excitotoxicity in autism spectrum disorder: disruption of glutamatergic homeostasis and the therapeutic role of the selenium-glutathione axis.Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2026
    Review
  8. Glial Cells in Behavioral and Psychological Symptoms of Alzheimer's Disease.International journal of molecular sciences · 2026
    Review
  9. Article
  10. Article
  11. Review
  12. Amyloid-Frontiers in neuroscience · 2026
    Review
  13. Review
  14. Article
  15. Review
  16. Article
  17. Review
  18. Article
  19. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Xiaoyan ZengSchool of Biomedical Sciences, The Chinese University of Hong Kong, Room G03, Lo Kwee-Seong Integrated Biomedical Sciences Building, Hong Kong SAR, China.
Stanley K K CheungSchool of Biomedical Sciences, The Chinese University of Hong Kong, Room G03, Lo Kwee-Seong Integrated Biomedical Sciences Building, Hong Kong SAR, China.
Mengqi ShiSchool of Life Science and Technology, Weifang Medical University, Shandong, China.
Penelope M Y OrSchool of Biomedical Sciences, The Chinese University of Hong Kong, Room G03, Lo Kwee-Seong Integrated Biomedical Sciences Building, Hong Kong SAR, China.
Zhining LiSchool of Biomedical Sciences, The Chinese University of Hong Kong, Room G03, Lo Kwee-Seong Integrated Biomedical Sciences Building, Hong Kong SAR, China.
Julia Y H LiuSchool of Biomedical Sciences, The Chinese University of Hong Kong, Room G03, Lo Kwee-Seong Integrated Biomedical Sciences Building, Hong Kong SAR, China.
Wayne L H HoSchool of Biomedical Sciences, The Chinese University of Hong Kong, Room G03, Lo Kwee-Seong Integrated Biomedical Sciences Building, Hong Kong SAR, China.
Tian LiuSchool of Biomedical Sciences, The Chinese University of Hong Kong, Room G03, Lo Kwee-Seong Integrated Biomedical Sciences Building, Hong Kong SAR, China.
Kun LuSchool of Life Science and Technology, Weifang Medical University, Shandong, China.
John A RuddSchool of Biomedical Sciences, The Chinese University of Hong Kong, Room G03, Lo Kwee-Seong Integrated Biomedical Sciences Building, Hong Kong SAR, China.
Yubing WangSchool of Life Science and Technology, Weifang Medical University, Shandong, China. ybwang@wfmc.edu.cn.
Andrew M ChanSchool of Biomedical Sciences, The Chinese University of Hong Kong, Room G03, Lo Kwee-Seong Integrated Biomedical Sciences Building, Hong Kong SAR, China. andrewmchan@cuhk.edu.hk.

Funding

Natural Science Foundation of Shandong Province ZR2020MH146Research Grants Council, University Grants Committee 14123718
6 · The paper itself

Abstract

Glial cell-mediated neuroinflammation and neuronal attrition are highly correlated with cognitive impairment in Alzheimer's disease. YKL-40 is a secreted astrocytic glycoprotein that serves as a diagnostic biomarker of Alzheimer's disease. High levels of YKL-40 are associated with either advanced Alzheimer's disease or the normal aging process. However, the functional role of YKL-40 in Alzheimer's disease development has not been firmly established. In a 5xFAD mouse model of Alzheimer's disease, we observed increased YKL-40 expression in the cerebrospinal fluid of 7-month-old mice and was correlated with activated astrocytes. In primary astrocytes, Aβ

Indexed as

Alzheimer DiseaseAmyloid beta-PeptidesAmyloid beta-Protein PrecursorAnimalsAstrocytesBiomarkersChitinase-3-Like Protein 1Disease Models, AnimalHumansInfantMiceMice, TransgenicAmyloid beta-PeptidesAmyloid beta-Protein PrecursorBiomarkersChil1 protein, mouseChitinase-3-Like Protein 1Alzheimer’s diseaseAmyloid-betaAstrocyteYKL-40

Identifiers

PMID38042775
PMCPMC10693711

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.