Evidence map›Paper›PMID 38042764›Full record

ArticleNeuroinformatics2024

A Deep Learning-Based Ensemble Method for Early Diagnosis of Alzheimer's Disease using MRI Images.

Sina Fathi, Ali Ahmadi, Afsaneh Dehnad, Mostafa Almasi-Dooghaee, Melika Sadegh, Alzheimer’s Disease Neuroimaging Initiative

Open access · hybridAbstract read
In one paragraph

Article in Neuroinformatics, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed, 1 pooled it
7.5field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 1 synthesis or guideline pooled it, 61 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 2 countries.

Sina FathiDepartment of Health Information Management, School of Allied Medical Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Ali AhmadiSurrey Business School, University of Surrey, Guildford Surrey, GU2 7XH, UK. a.ahmadi@surrey.ac.uk.
Afsaneh DehnadSchool of Health Management and Information Sciences, Iran University of Medical Sciences, Tehran, Iran.
Mostafa Almasi-DooghaeeNeurology Department, Firoozgar Hospital, School of Medicine, Iran University of Medical Sciences, Tehran, Iran.
Melika SadeghNeurology Department, Firoozgar Hospital, School of Medicine, Iran University of Medical Sciences, Tehran, Iran.
Alzheimer’s Disease Neuroimaging Initiative
Iran University of Medical Sciences · IRShahid Beheshti University of Medical Sciences · IRUniversity of Surrey · GB

Funding

Alzheimer's Disease Neuroimaging Initiative - SupplementU01AG024904 · NIA · NORTHERN CALIFORNIA INSTITUTE RES &EDUC · PI WEINER, MICHAEL W · 2004 to 2015
$121.0M
NIA NIH HHS U01 AG024904
6 · The paper itself

Abstract

Recently, the early diagnosis of Alzheimer's disease has gained major attention due to the growing prevalence of the disease and the resulting costs imposed on individuals and society. The main objective of this study was to propose an ensemble method based on deep learning for the early diagnosis of AD using MRI images. The methodology of this study consisted of collecting the dataset, preprocessing, creating the individual and ensemble models, evaluating the models based on ADNI data, and validating the trained model based on the local dataset. The proposed method was an ensemble approach selected through a comparative analysis of various ensemble scenarios. Finally, the six best individual CNN-based classifiers were selected to combine and constitute the ensemble model. The evaluation showed an accuracy rate of 98.57, 96.37, 94.22, 99.83, 93.88, and 93.92 for NC/AD, NC/EMCI, EMCI/LMCI, LMCI/AD, four-way and three-way classification groups, respectively. The validation results on the local dataset revealed an accuracy of 88.46 for three-way classification. Our performance results were higher than most reviewed studies and comparable with others. Although comparative analysis showed superior results of ensemble methods against individual architectures, there were no significant differences among various ensemble approaches. The validation results revealed the low performance of individual models in practice. In contrast, the ensemble method showed promising results. However, further studies on various and larger datasets are required to validate the generalizability of the model.

Indexed as

Alzheimer DiseaseCognitive DysfunctionDeep LearningEarly DiagnosisHumansMagnetic Resonance ImagingAlzheimer’s diseaseConvolutional neural networksDeep learningMagnetic resonance imagingMild Cognitive ImpairmentTransfer learning

Identifiers

PMID38042764
PMCPMC10917836
OpenAlexW4389265315

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.