Evidence map›Paper›PMID 38042492›Full record

ArticleThe Journal of biological chemistry2024

TRIM54 alleviates inflammation and apoptosis by stabilizing YOD1 in rat tendon-derived stem cells.

Hua Chen, Xiaofeng Chen, Ling Yang, Shiyang Sheng, Jianshe Yang, Yong Lu, Yangbai Sun, Xiaoping Zhang, Chaoyin Jiang

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of biological chemistry, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.5field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 1 country.

Hua ChenDepartment of Orthopedics, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Xiaofeng ChenDepartment of Orthopaedic Surgery, Hainan Province Clinical Medical Center, Sanya, China; Haikou Orthopedic and Diabetes Hospital of Shanghai Sixth People's Hospital, Haikou, China.
Ling YangDepartment of Nuclear Medicine, Shanghai Tenth People's Hospital, Tongji University, Shanghai, China.
Shiyang ShengDepartment of Nuclear Medicine, Shanghai Tenth People's Hospital, Tongji University, Shanghai, China.
Jianshe YangDepartment of Nuclear Medicine, Shanghai Tenth People's Hospital, Tongji University, Shanghai, China.
Yong LuDepartment of Radiology, Ruijin Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China; Department of Radiology, Ruijin Hospital Luwan Branch, School of Medicine, Shanghai Jiao Tong University, Shanghai, China. Electronic address: 18917762053@163.com.
Yangbai SunDepartment of Musculoskeletal Oncology, Fudan University Shanghai Cancer Center, Shanghai, China; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China. Electronic address: drsunyb@fudan.edu.cn.
Xiaoping ZhangThe Institute of Intervention Vessel, Tongji University School of Medicine, Shanghai, China.
Chaoyin JiangDepartment of Orthopedics, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China; Department of Orthopaedic Surgery, Hainan Province Clinical Medical Center, Sanya, China. Electronic address: jiangchaoyin@shsmu.edu.cn.
Tongji University · CNShanghai Jiao Tong University · CNHaikou City People's Hospital · CNShanghai Medical College of Fudan University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Tendinopathy is a disorder of musculoskeletal system that primarily affects athletes and the elderly. Current treatment options are generally comprised of various exercise and loading programs, therapeutic modalities, and surgical interventions and are limited to pain management. This study is to understand the role of TRIM54 (tripartite motif containing 54) in tendonitis through in vitro modeling with tendon-derived stem cells (TDSCs) and in vivo using rat tendon injury model. Initially, we observed that TRIM54 overexpression in TDSCs model increased stemness and decreased apoptosis. Additionally, it rescued cells from tumor necrosis factor α-induced inflammation, migration, and tenogenic differentiation. Further, through immunoprecipitation studies, we identified that TRIM54 regulates inflammation in TDSCs by binding to and ubiquitinating YOD1. Further, overexpression of TRIM54 improved the histopathological score of tendon injury as well as the failure load, stiffness, and young modulus in vivo. These results indicated that TRIM54 played a critical role in reducing the effects of tendon injury. Consequently, these results shed light on potential therapeutic alternatives for treating tendinopathy.

Indexed as

EndopeptidasesMuscle ProteinsTendinopathyThiolester HydrolasesAgedAnimalsApoptosisCell DifferentiationHumansRatsStem CellsTendon InjuriesTendonsEndopeptidasesMuscle ProteinsThiolester HydrolasesYOD1 protein, humanapoptosistendinopathytendon-derived stem cellsTRIM54YOD1

Identifiers

PMID38042492
PMCPMC10801318
OpenAlexW4389160546

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.