Evidence map›Paper›PMID 38042297›Full record

ArticleThe ocular surface2024

Modeling meibum secretion: Alternatives for obstructive Meibomian Gland Dysfunction (MGD).

Shangbang Luo, Gagik P Djotyan, Rohan Joshi, Tibor Juhasz, Donald J Brown, James V Jester

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The ocular surface, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
2.3field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it, 8 citations in OpenAlex.

  1. Pooled it
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  3. Article
  4. Article
  5. Review
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Shangbang LuoDepartment of Ophthalmology, University of California, Irvine, CA, USA; Department of Biomedical Engineering, University of California, Irvine, CA, USA.
Gagik P DjotyanInstitute for Particle & Nuclear Physics, Wigner Research Center, Budapest, Hungary.
Rohan JoshiDepartment of Ophthalmology, University of California, Irvine, CA, USA; Department of Biomedical Engineering, University of California, Irvine, CA, USA.
Tibor JuhaszDepartment of Ophthalmology, University of California, Irvine, CA, USA; Department of Biomedical Engineering, University of California, Irvine, CA, USA.
Donald J BrownDepartment of Ophthalmology, University of California, Irvine, CA, USA.
James V JesterDepartment of Ophthalmology, University of California, Irvine, CA, USA; Department of Biomedical Engineering, University of California, Irvine, CA, USA. Electronic address: jjester@hs.uci.edu.
University of California, Irvine · USInstitute for Particle and Nuclear Physics · HU

Funding

Age-Related Meibomian Gland DysfunctionR01EY021510 · NEI · UNIVERSITY OF CALIFORNIA-IRVINE · PI James V Jester · 2011 to 2026
$4.8M
NEI UCI Center Core Grant for Vision ResearchP30EY034070 · NEI · UNIVERSITY OF CALIFORNIA-IRVINE · PI Vladimir Jivkov Kefalov · 2022 to 2026
$3.7M
Non-Invasive Femtosecond Laser Glaucoma Surgery Guided by Micron-Resolution OCTR01EY030304 · NEI · UNIVERSITY OF CALIFORNIA-IRVINE · PI JUHASZ, TIBOR · 2019 to 2022
$1.9M
NEI NIH HHS P30 EY034070NEI NIH HHS R01 EY021510NEI NIH HHS R01 EY030304
6 · The paper itself

Abstract

purposeWhile changes in meibum quality are correlated with severity of meibomian gland dysfunction (MGD) and dry eye disease, little is known regarding the mechanics of meibum secretion. The purpose of this study was to develop a finite element model of meibum secretion and evaluate the effect of various factors that might impact meibum delivery to the ocular surface.

methodsA finite element analysis in COMSOL 6.0 was used to simulate the flow of meibum within the gland's terminal excretory duct. Historical normal human meibum rheology data taken over the meibum melting range from fluid (35-40 °C) to solid (25-30 °C) were then used to calculate the minimum yield stress and plastic viscosity of meibum. The effects of meibum melting state, eyelid pressure and terminal duct diameter on meibum flow rates were then systematically investigated.

resultsThe melting state of meibum from liquid to solid was associated with an increase in the minimum yield stress and plastic viscosity that caused an exponential decrease in meibum flow. Modeling also established that there was a linear correlation between meibum flow rate and eyelid pressure needed to express meibum and the 4th power of the terminal duct radius.

conclusionsOur results suggest that changes in the melting state of meibum from fluid to solid, as well as changes in the radius of the terminal excretory duct and the force exerted by the eyelid can lead to dramatic decreases in the flow of meibum. Together these findings suggest alternative mechanisms for meibomian gland obstruction.

Indexed as

Dry Eye SyndromesEyelid DiseasesMeibomian Gland DysfunctionHumansMeibomian GlandsTearsEyelid blink pressureFinite element analysisFlow rateMeibomian gland dysfunctionMeibumModelingNon-NewtonianOrificeTerminal ductViscosity

Identifiers

PMID38042297
PMCPMC11955202
OpenAlexW4389209620

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.