ArticleThe Plant cell2024
The m6A reader ECT1 drives mRNA sequestration to dampen salicylic acid-dependent stress responses in Arabidopsis.
Article in The Plant cell, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.
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Who cites it
45 citing papers in PubMed, 71 citations in OpenAlex.
- RNA m6A methylation fine-tunes the jasmonic acid biosynthesis pathway to modulate plant aging.The Plant cell · 2026Article
- Biomolecular condensates in plant stress and development: recent advances and emerging concepts.Journal of experimental botany · 2026Review
- Mechanisms and balanced regulation of plant immunity.Nature reviews. Molecular cell biology · 2026Review
- Phytochrome B and the methyltransferase complex coordinately regulate NPlant communications · 2026Article
- A practical guide to investigating biomolecular condensates: a comment from the plant community.Science China. Life sciences · 2026Review
- RNA regulation in plants.Science China. Life sciences · 2026Review
- RNA modifications and epigenetic regulation in plants.aBIOTECH · 2026Review
- Dual Roles of mCells · 2026Review
- Genome-Wide Analysis of YTH Domain Proteins inPlants (Basel, Switzerland) · 2026Article
- Cold storage delays peach fruit softening via mMolecular horticulture · 2026Article
- Comprehensive Genomic Characterization of mInternational journal of molecular sciences · 2026Article
- CDS-localized mNature plants · 2026Article
- Sensing and Filtering Environmental Fluctuations: The Case of Biomolecular Condensates in Plants.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Review
- Prediction of plant phase-separating proteins using positive-unlabeled learning.Genome biology · 2026Article
- Fluorescence-activated particle sorting for condensate purification.Nature protocols · 2026Review
- Potyviruses recruit host eIF4A3 to block m6A-mediated RNA decay by steric hindrance of viral RNA methylation in plants.Nucleic acids research · 2026Article
- Phase separation in plants: mechanisms, functions, and a simplified workflow for investigation.Frontiers in plant science · 2026Review
- Comprehensive Genome-Wide Identification and Expression Analysis of the N6-Methyladenosine (m6A) Regulatory Network Influences Rapid Stress Adaptation With Exogenous Melatonin in Rice.Journal of pineal research · 2026Article
- Salicylic acid and ROS signaling modulate hypocotyl elongation in darkness via NPR1 and EX1.Science advances · 2025Article
- Role of mEpigenomes · 2025Review
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Authors and funding
14 authors at 1 institution in 1 country.
Funding
Abstract
N 6-methyladenosine (m6A) is a common epitranscriptional mRNA modification in eukaryotes. Thirteen putative m6A readers, mostly annotated as EVOLUTIONARILY CONSERVED C-TERMINAL REGION (ECT) proteins, have been identified in Arabidopsis (Arabidopsis thaliana), but few have been characterized. Here, we show that the Arabidopsis m6A reader ECT1 modulates salicylic acid (SA)-mediated plant stress responses. ECT1 undergoes liquid-liquid phase separation in vitro, and its N-terminal prion-like domain is critical for forming in vivo cytosolic biomolecular condensates in response to SA or bacterial pathogens. Fluorescence-activated particle sorting coupled with quantitative PCR analyses unveiled that ECT1 sequesters SA-induced m6A modification-prone mRNAs through its conserved aromatic cage to facilitate their decay in cytosolic condensates, thereby dampening SA-mediated stress responses. Consistent with this finding, ECT1 overexpression promotes bacterial multiplication in plants. Collectively, our findings unequivocally link ECT1-associated cytosolic condensates to SA-dependent plant stress responses, advancing the current understanding of m6A readers and the SA signaling network.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.