Evidence map›Paper›PMID 38041861›Full record

ReviewAlzheimer's & dementia : the journal of the Alzheimer's Association2024

When the central integrator disintegrates: A review of the role of the thalamus in cognition and dementia.

J Matthijs Biesbroek, Marieke G Verhagen, Stefan van der Stigchel, Geert Jan Biessels

Open access · hybridAbstract readReview
In one paragraph

Review in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
40citing papers in PubMed, 1 pooled it
7.7field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

40 citing papers in PubMed, 1 synthesis or guideline pooled it, 52 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Thalamic Nuclei Atrophy in Type 1 Diabetes Mellitus Across Disease Duration.Journal of magnetic resonance imaging : JMRI · 2026
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  4. Article
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  9. Genetically linked brain imaging markers of memory decline in aging and Alzheimer's disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026
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  15. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 2 countries.

J Matthijs BiesbroekDepartment of Neurology, UMC Utrecht Brain Center, University Medical Center Utrecht, Utrecht, The Netherlands.ORCID 0000-0001-7017-2148
Marieke G VerhagenVIB Center for Brain and Disease, Leuven, Belgium.ORCID 0000-0002-6871-1330
Stefan van der StigchelDepartment of Experimental Psychology, Helmholtz Institute, Utrecht University, Utrecht, The Netherlands.
Geert Jan BiesselsDepartment of Neurology, UMC Utrecht Brain Center, University Medical Center Utrecht, Utrecht, The Netherlands.
University Medical Center Utrecht · NLUtrecht University · NLVIB-KU Leuven Center for Brain & Disease Research · BE

Funding

ZonMw 10510032120003
6 · The paper itself

Abstract

The thalamus is a complex neural structure with numerous anatomical subdivisions and intricate connectivity patterns. In recent decades, the traditional view of the thalamus as a relay station and "gateway to the cortex" has expanded in recognition of its role as a central integrator of inputs from sensory systems, cortex, basal ganglia, limbic systems, brain stem nuclei, and cerebellum. As such, the thalamus is critical for numerous aspects of human cognition, mood, and behavior, as well as serving sensory processing and motor functions. Thalamus pathology is an important contributor to cognitive and functional decline, and it might be argued that the thalamus has been somewhat overlooked as an important player in dementia. In this review, we provide a comprehensive overview of thalamus anatomy and function, with an emphasis on human cognition and behavior, and discuss emerging insights on the role of thalamus pathology in dementia.

Indexed as

CognitionDementiaCerebral CortexHumansNeural PathwaysThalamuscognitiondementiafunctional anatomyneuroanatomythalamus

Identifiers

PMID38041861
PMCPMC10984498
OpenAlexW4389263680

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.