Evidence map›Paper›PMID 38041478›Full record

ArticleMolecular oral microbiology2024

Filifactor alocis enhances survival of Porphyromonas gingivalis W83 in response to H

Arunima Mishra, Yuetan Dou, Charles Wang, Hansel M Fletcher

Abstract read
In one paragraph

Article in Molecular oral microbiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Functional Characterization of a Putative Sortase FA1364 inInternational journal of molecular sciences · 2026
    Article
  2. Journal of dental research · 2025
    Article
  3. Review
  4. Increased bacterial load ofFrontiers in oral health · 2025
    Article
  5. Association ofFrontiers in cellular and infection microbiology · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Arunima MishraDivision of Microbiology & Molecular Genetics, School of Medicine, Loma Linda University, Loma Linda, California, USA.ORCID 0009-0001-1768-9954
Yuetan DouDivision of Microbiology & Molecular Genetics, School of Medicine, Loma Linda University, Loma Linda, California, USA.
Charles WangDepartment of Basic Sciences, School of Medicine, Center for Genomics, Loma Linda University, Loma Linda, California, USA.
Hansel M FletcherDivision of Microbiology & Molecular Genetics, School of Medicine, Loma Linda University, Loma Linda, California, USA.

Funding

Studies on the virulence regulation in PorphyromonasR01DE025852 · NIDCR · LOMA LINDA UNIVERSITY · PI FLETCHER, HANSEL M. · 2016 to 2020
$2.0M
Mechanisms for the repair of oxidative stress-induced DNA damage in PorphyromonasR21DE030411 · NIDCR · LOMA LINDA UNIVERSITY · PI FLETCHER, HANSEL M. · 2021 to 2022
$435k
Oxidative Stress Resistance Mechanisms in Filifactor AlocisR03DE029825 · NIDCR · LOMA LINDA UNIVERSITY · PI MISHRA, ARUNIMA · 2021 to 2022
$316k
NIDCR NIH HHS R01 DE025852NIDCR NIH HHS R03 DE029825NIDCR NIH HHS R21 DE030411
6 · The paper itself

Abstract

A dysbiotic microbial community whose members have specific/synergistic functions that are modulated by environmental conditions, can disturb homeostasis in the subgingival space leading to destructive inflammation, plays a role in the progression of periodontitis. Filifactor alocis, a gram-positive, anaerobic bacterium, is a newly recognized microbe that shows a strong correlation with periodontal disease. Our previous observations suggested F. alocis to be more resistant to oxidative stress compared to Porphyromonas gingivalis. The objective of this study is to further determine if F. alocis, because of its increased resistance to oxidative stress, can affect the survival of other 'established' periodontal pathogens under environmental stress conditions typical of the periodontal pocket. Here, we have shown that via their interaction, F. alocis protects P. gingivalis W83 under H

Indexed as

Gram-Positive BacteriaPorphyromonas gingivalisATP-Binding Cassette TransportersBase CompositionEubacterialesHumansPeriodontal PocketPhylogenyRNA, Ribosomal, 16SSequence Analysis, DNAATP-Binding Cassette TransportersRNA, Ribosomal, 16SFilifactor alocisH2O2-induced oxidative stressoral pathogenperiodontitisPorphyromonas gingivalis

Identifiers

PMID38041478
PMCPMC10842171

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.