Evidence map›Paper›PMID 38041477›Full record

ArticleMagnetic resonance in medicine2024

The impact of water exchange on estimates of myocardial extracellular volume calculated using contrast enhanced T

Noor Sharrack, John D Biglands, David A Broadbent, Peter Kellman, Kelvin Chow, John P Greenwood, Eylem Levelt, Sven Plein, David L Buckley

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Magnetic resonance in medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed, 1 pooled it
0.9field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 synthesis or guideline pooled it, 4 citations in OpenAlex.

  1. Pooled it
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

Noor SharrackBiomedical Imaging, Leeds Institute of Cardiovascular and Metabolic Medicine, University of Leeds, Leeds, UK.ORCID 0000-0001-5880-1722
John D BiglandsBiomedical Imaging, Leeds Institute of Cardiovascular and Metabolic Medicine, University of Leeds, Leeds, UK.
David A BroadbentBiomedical Imaging, Leeds Institute of Cardiovascular and Metabolic Medicine, University of Leeds, Leeds, UK.
Peter KellmanNational Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland, USA.
Kelvin ChowCardiovascular MR R&D, Siemens Medical Solutions USA, Inc., Chicago, Illinois, USA.ORCID 0000-0003-0698-1746
John P GreenwoodBiomedical Imaging, Leeds Institute of Cardiovascular and Metabolic Medicine, University of Leeds, Leeds, UK.
Eylem LeveltBiomedical Imaging, Leeds Institute of Cardiovascular and Metabolic Medicine, University of Leeds, Leeds, UK.ORCID 0000-0002-3799-7102
Sven PleinBiomedical Imaging, Leeds Institute of Cardiovascular and Metabolic Medicine, University of Leeds, Leeds, UK.
David L BuckleyBiomedical Imaging, Leeds Institute of Cardiovascular and Metabolic Medicine, University of Leeds, Leeds, UK.ORCID 0000-0001-6659-8365
University of Leeds · GBMedical Solutions · GBNational Institutes of Health · US

Funding

Gadgetron Global Network and Intelligence Computing: Clinical Imaging Application Development and Software InfrastructureZIAHL006214 · NHLBI · NATIONAL HEART, LUNG, AND BLOOD INSTITUTE · PI KELLMAN, PETER · 2016 to 2025
$7.3M
British Heart Foundation CH/16/2/32089British Heart Foundation PG/20/10008British Heart Foundation RG/16/1/32092Intramural NIH HHS Z99 HL999999
6 · The paper itself

Abstract

purposeGuidelines recommend measuring myocardial extracellular volume (ECV) using T

methodsTwenty-five patients with severe AS and 5 healthy controls were recruited. T

resultsMedian (range) ECV estimated using the 2SXM model was 25% (21%-39%) for patients and 26% (22%-29%) for controls. ECV estimated in patients using the LM at 10 min following a cumulative contrast dose of 0.15 mmol/kg was 21% (17%-32%) and increased significantly to 22% (19%-35%) at 30 min (p = 0.0001). ECV estimated using the LM was highest following low dose gadobutrol, 25% (19%-38%).

conclusionCurrent guidelines on contrast agent dose for ECV measurements may lead to underestimated ECV in patients with severe AS because of limited WX. Use of a lower contrast agent dose may mitigate this effect.

Indexed as

Aortic Valve StenosisOrganometallic CompoundsContrast MediaHumansMagnetic Resonance Imaging, CineMyocardiumPredictive Value of TestsContrast MediagadobutrolOrganometallic Compoundsaortic stenosisextracellular volumeT1water exchange

Identifiers

PMID38041477
PMCPMC10872615
OpenAlexW4389270414

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.