Evidence map›Paper›PMID 38041408›Full record

ArticleEuropean journal of public health2024

Mortality among people who inject drugs - the interwoven roles of fentanyl and HIV: a community-based cohort study.

Maris Salekešin, Sigrid Vorobjov, Don Des Jarlais, Anneli Uusküla

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Article in European journal of public health, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

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2citing papers in PubMed
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1 · What the graph read from it

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2 · The registry

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3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

4 authors.

Maris SalekešinDepartment of Risk Behavior Studies, National Institute for Health Development, Tallinn, Estonia.ORCID 0000-0002-8578-0928
Sigrid VorobjovDepartment of Risk Behavior Studies, National Institute for Health Development, Tallinn, Estonia.
Don Des JarlaisSchool of Global Public Health, New York University, New York, USA.
Anneli UuskülaInstitute of Family Medicine and Public Health, University of Tartu, Tartu, Estonia.ORCID 0000-0002-4036-3856

Funding

Combined prevention to reduce initiation into injecting drug useDP1DA039542 · NIDA · NEW YORK UNIVERSITY · PI DES JARLAIS, DON C · 2015 to 2019
$4.1M
Multiple HIV Prevention Packages for IDUs in EstoniaR01AI083035 · NIAID · BETH ISRAEL MEDICAL CTR (NEW YORK) · PI DES JARLAIS, DON C · 2009 to 2012
$2.5M
NIAID NIH HHS R01 AI083035NIDA NIH HHS DP1 DA039542NIDA NIH HHS R01-AI083035
6 · The paper itself

Abstract

backgroundExcess all-cause mortality is a key indicator for assessing direct and indirect consequences of injection drug use and data are warranted to delineate sub-populations within people who inject drugs at higher risk of death. Our aim was to examine mortality and factors associated with mortality among people who inject drugs in Estonia.

methodsRetrospective cohort study using data from people who inject drugs recruited in the community with linkage to death records. Standardized mortality ratios were used to compare the cohort mortality to the general population and potential predictors of death were examined through survival analysis (Cox regression). The cohort include a total of 1399 people who inject drugs recruited for cross-sectional surveys using respondent driven sampling between 2013 and 2018 in Estonia. A cohort with follow-up through 2019 was formed with linkage to national causes of death registry.

resultsAmong 1399 participants with 4684 person-years of follow-up, 10% were deceased by 2019. The all-cause mortality rate in the cohort was 28.9 per 1000 person-years (95% confidence interval 25.3-35.3). Being HIV positive, injecting mainly opioids (fentanyl), living in the capital region and the main source of income other than work were associated with greater mortality risk.

conclusionsWhile low-threshold services have been available for a long time for people who inject drugs, there is still a need to widen the availability and integration of services, particularly the integration of HIV and opioid treatment.

Indexed as

Drug UsersHIV InfectionsSubstance Abuse, IntravenousAnalgesics, OpioidCohort StudiesCross-Sectional StudiesFentanylHumansRetrospective StudiesAnalgesics, OpioidFentanyl

Identifiers

PMID38041408
PMCPMC10990538

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.