ArticleCerebral cortex (New York, N.Y. : 1991)2024
Functional and anatomical connectivity predict brain stimulation's mnemonic effects.
Article in Cerebral cortex (New York, N.Y. : 1991), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- Structural and Functional Connectivity Predict the Effects of Direct Brain Stimulation on Memory.bioRxiv : the preprint server for biology · 2026Article
- Network hubs supporting memory encoding: Implications for cognitive preservation in epilepsy surgery.Epilepsia · 2026Article
- Brain stimulation preferentially influences long-range projections.Science advances · 2025Article
- Closed-loop control of theta oscillations enhances human hippocampal network connectivity.Nature communications · 2025Article
- Synchronous Theta Networks Characterize Successful Memory Retrieval.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- High-gamma and beta bursts in the left supramarginal gyrus can differentiate verbal memory states and performance.Frontiers in neurology · 2025Article
- Why does invasive brain stimulation sometimes improve memory and sometimes impair it?PLoS biology · 2024Article
- Merritt-Putnam Symposium | Developmental and Epileptic Encephalopathies-Current Concepts and Novel Approaches.Epilepsy currentsReview
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Funding
Abstract
Closed-loop direct brain stimulation is a promising tool for modulating neural activity and behavior. However, it remains unclear how to optimally target stimulation to modulate brain activity in particular brain networks that underlie particular cognitive functions. Here, we test the hypothesis that stimulation's behavioral and physiological effects depend on the stimulation target's anatomical and functional network properties. We delivered closed-loop stimulation as 47 neurosurgical patients studied and recalled word lists. Multivariate classifiers, trained to predict momentary lapses in memory function, triggered the stimulation of the lateral temporal cortex (LTC) during the study phase of the task. We found that LTC stimulation specifically improved memory when delivered to targets near white matter pathways. Memory improvement was largest for targets near white matter that also showed high functional connectivity to the brain's memory network. These targets also reduced low-frequency activity in this network, an established marker of successful memory encoding. These data reveal how anatomical and functional networks mediate stimulation's behavioral and physiological effects, provide further evidence that closed-loop LTC stimulation can improve episodic memory, and suggest a method for optimizing neuromodulation through improved stimulation targeting.
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