ArticleMalaria journal2023
UPLC/ESI/MS profiling of red algae Galaxaura rugosa extracts and its activity against malaria mosquito vector, Anopheles pharoensis, with reference to Danio rerio and Daphnia magna as bioindicators.
Article in Malaria journal, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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10 citing papers in PubMed, 18 citations in OpenAlex.
- Phytochemical profiling, metabolomics, and molecular docking studies of Atriplex halimus aerial parts revealing potential insecticidal activity against the malaria vector Anopheles pharoensis.Scientific reports · 2026Article
- Laboratory efficacy of green-synthesized silver and copper nanoparticles against malaria vector,Open veterinary journal · 2026Article
- Comparative UPLC/MSScientific reports · 2026Article
- Repellent and insecticidal activities of Pinus halepensis and Cupressus sempervirens extracts against the West Nile virus vector Culex pipiens.Scientific reports · 2025Article
- Harnessing Marine Algae for Sustainable Agriculture: Natural Bioactive Compounds as Eco-Friendly Pesticidal Agents.Marine drugs · 2025Review
- Sustainable MnOPharmaceuticals (Basel, Switzerland) · 2025Article
- UPLC/MSScientific reports · 2025Article
- Seasonal variation effect on different Physalis peruviana L. (Solanaceae) waste extracts and investigation of their efficacy against Culex pipiens and Musca domestica.Scientific reports · 2025Article
- Greenness assessment and phototoxicity of rose bengal and methylene blue on immature aquatic stages of malaria vector Anopheles pharoensis.Scientific reports · 2025Article
- Study of the effect of dryness and storage on Ceratonia siliqua L. stem extracts and evaluation of their insecticidal activity.Scientific reports · 2025Article
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Authors and funding
11 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAnopheles pharoensis has a major role in transmitting several human diseases, especially malaria, in Egypt?. Controlling Anopheles is considered as an effective strategy to eliminate the spread of malaria worldwide. Galaxaura rugosa is a species of red algae found in tropical to subtropical marine environments. The presence of G. rugosa is indicative of the ecosystem's overall health. The current work aims to investigate UPLC/ESI/MS profile of G. rugosa methanol and petroleum ether extracts and its activity against An. pharoensis and non-target organisms, Danio rerio and Daphnia magna.
methodsGalaxaura rugosa specimens have been identified using DNA barcoding for the COI gene and verified as G. rugosa. The UPLC/ESI/MS profiling of G. rugosa collected from Egypt was described. The larvicidal and repellent activities of G. rugosa methanol and petroleum ether extracts against An. pharoensis were evaluated, as well as the toxicity of tested extracts on non-target organisms, Dan. rerio and Dap. magna.
resultsThe UPLC/ESI/MS analysis of methanol and petroleum ether extracts led to the tentative identification of 57 compounds belonging to different phytochemical classes, including flavonoids, tannins, phenolic acids, phenyl propanoids. Larval mortality was recorded at 93.33% and 90.67% at 80 and 35 ppm of methanol and petroleum ether extracts, respectively, while pupal mortality recorded 44.44 and 22.48% at 35 and 30 ppm, respectively. Larval duration was recorded at 5.31 and 5.64 days by methanol and petroleum ether extracts at 80 and 35 ppm, respectively. A decrease in acetylcholinesterase (AChE) level and a promotion in Glutathione-S-transferase (GST) level of An. pharoensis 3rd instar larvae were recorded by tested extracts. The petroleum ether extract was more effective against An. pharoensis starved females than methanol extract. Also, tested extracts recorded LC
conclusionsUsing red algae derivatives in An. pharoensis control could reduce costs and environmental impact and be harmless to humans and other non-target organisms.
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