ArticleBMC oral health2023
Effect of thermal manipulation on the biological and mechanical characteristics of horizontal platelet rich fibrin membranes.
Article in BMC oral health, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 5 citations in OpenAlex.
- Wound Healing Patterns of PRF and PRGF Versus a Collagen-Based Substitute and Spontaneous Healing-A Randomised Controlled Clinical Trial Assessing Wound Closure of an Experimental, Standardised Palatal Defect.Journal of clinical periodontology · 2026Trial
- Comparing two types of platelet-rich fibrin membranes in the management of dehiscence defects with simultaneous implant placement in the posterior mandible: a randomized controlled trial.BMC oral health · 2026Trial
- Effects of a Xenogeneic Bone Graft Combined with Platelet-Rich Fibrin Obtained Using Two Distinct Centrifugation Protocols on Critical-Size Rat Calvarial Defects: A Microtomographic, Histomorphometric, and Confocal Laser Scanning Microscopy Analysis.Journal of functional biomaterials · 2026Article
- Platelet-rich fibrin-derived extracellular vesicles: emerging biological mediators in periodontal regeneration.Odontology · 2026Review
- A scoping review on platelet-rich fibrin-driven bone regeneration: biological mechanisms and clinical applications in oral and maxillofacial surgery.Journal of the Korean Association of Oral and Maxillofacial Surgeons · 2026Article
- Stored L-PRF membranes: safety, morphology, tensile properties, and cell viability-an in vitro pilot study.Scientific reports · 2026Article
- Impact of Thermal Treatment on Growth Factor Levels in Injectable Horizontal Platelet-Rich Fibrin: An In Vitro Study.Clinical and experimental dental research · 2026Article
- Antibacterial Activity of Fresh and Autoclaved Platelet-Rich Fibrin on Pseudomonas aeruginosa: An In Vitro Study.Journal of clinical laboratory analysis · 2026Article
- Plasma-Coated Collagen Membranes Gain Barrier Function Through Heat Treatment.Journal of functional biomaterials · 2026Article
- Biological impact of adding albumin and silver nanoparticles to concentrated growth factors.BMC oral health · 2026Article
- Advantages of horizontal centrifugation of platelet-rich fibrin in regenerative medicine and dentistry.Periodontology 2000 · 2025Review
- Tensile Strength, Cellular Content and Degradation properties in three generations of concentrated growth factors.BMC oral health · 2025Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroudRegardless of application scenarios, proper mechanical characteristics and degradation properties are prerequisites for horizontal platelet rich fibrin (H-PRF) to manifest its ability. Among the methods used to modify PRF, thermal manipulation is promising as it is easy to handle without adding extra additives. Yet there is no consensus on optimal temperature treatment. This study aimed to investigate the effects of heating on the biological and mechanical characteristics of H-PRF and explore the optimum heating temperature for H-PRF thermal treatment.
methodsWe employed a series of temperature gradients, room temperature, 50℃, 75℃, 90℃, 105℃. The microstructure and the mechanical properties were recorded by Scanning Electron Microscope (SEM) and tensile strength tests respectively. The degradation rate of H-PRF membranes was examined by digestion assay with plasmin and trypsin. The viability of cells within H-PRF membranes and the proliferation of osteoblasts cultured with extracts from different H-PRF groups was evaluated using CCK-8 assays.
resultsCompared with the nonheated group, overheated manipulation beyond 90℃ can significantly prolong the degradation properties for up to 3 to 4 weeks and enhance the mass stress of H-PRF membranes. A high-temperature treatment of 105℃ accompanied by the cell activity beneath H-PRF reduced more than half, and thus, the biological effect on human osteoblasts (hFOBs) also reduced dramatically.
conclusionsHigh thermal manipulation can prolong the degradation properties and enhance the mechanical properties of PRF membranes accompanied by the loss of biological effect.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.