Evidence map›Paper›PMID 38040851›Full record

ArticleJournal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing2025

Modified sympathicotomy in patients with refractory ventricular tachycardia and structural heart disease: a single-center experience.

Filippo Maria Cauti, Pietro Rossi, Stefano Bianchi, Michele Magnocavallo, Silvia Capone, Domenico Giovanni Della Rocca, Marco Polselli, Katia Bruno, Pierfrancesco Tozzi, Chiara Rossi and 5 more

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Article in Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.1field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Article
  3. Neuromodulation for ventricular arrhythmias: progress-but are we there yet?Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing · 2025
    Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 6 institutions in 2 countries.

Filippo Maria CautiArrhythmology Department, IRCCS San Raffaele Scientific Institute, Milan, Italy. filippocauti@hotmail.it.
Pietro Rossi *Arrhythmology Unit, Fatebenefratelli Isola - Gemelli Isola, Rome, Italy.
Stefano BianchiArrhythmology Unit, Fatebenefratelli Isola - Gemelli Isola, Rome, Italy.
Michele MagnocavalloArrhythmology Unit, Fatebenefratelli Isola - Gemelli Isola, Rome, Italy.ORCID http://orcid.org/0000-0001-9883-0114
Silvia CaponeArrhythmology Unit, Fatebenefratelli Isola - Gemelli Isola, Rome, Italy.
Domenico Giovanni Della RoccaHeart Rhythm Management Centre, Postgraduate Program in Cardiac Electrophysiology and Pacing, Universitair Ziekenhuis Brussel-Vrije Universiteit Brussel, European Reference Networks Guard - Heart, Brussels, Belgium.
Marco PolselliArrhythmology Unit, Fatebenefratelli Isola - Gemelli Isola, Rome, Italy.
Katia BrunoDepartment of Anesthesiology, Sapienza University, Rome, Italy.
Pierfrancesco TozziDepartment of Anesthesiology, Sapienza University, Rome, Italy.
Chiara RossiPresidio Ospedaliero Santo Spirito in Sassia, Rome, Italy.
Jacopo VannucciDivision of Thoracic Surgery and Lung Transplant, Sapienza University, Rome, Italy.
Francesco PuglieseDepartment of Anesthesiology, Sapienza University, Rome, Italy.
Raffaele QuaglioneCardiology Unit, Dipartimento Cuore e Grossi Vasi, Policlinico Umberto I, Sapienza University, Rome, Italy.
Federico VenutaDivision of Thoracic Surgery and Lung Transplant, Sapienza University, Rome, Italy.
Marco AnileDivision of Thoracic Surgery and Lung Transplant, Sapienza University, Rome, Italy.
Sapienza University of Rome · ITFatebenefratelli Hospital · ITPoliclinico Umberto I · ITPresidio Ospedaliero · ITVita-Salute San Raffaele University · ITVrije Universiteit Brussel · BE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundModified cardiac sympathetic denervation (CSD) with stellate ganglion (SG) sparing is a novel technique for cardiac neuromodulation in patients with refractory ventricular tachycardia (VT).

objectivesOur aim is to describe the mid- to long-term clinical outcome of the modified CSD with SG sparing in a series of patients with structural heart disease (SHD) and refractory VT.

methodsAll consecutive patients with SHD and refractory VT undergoing modified CSD were enrolled. Baseline clinical characteristics and periprocedural data were collected for all patients. The primary outcome was any recurrence of sustained VT.

resultsWe enrolled 15 patients (age: 69.2 ± 7.9 years; male 100%) undergoing modified CSD. Left ventricular ejection fraction was 37 ± 11% and all patients had an implantable cardiac defibrillator (ICD); the underlying cardiomyopathy was non-ischemic in 73.3% of them. At least one previous ablation had been attempted in 66.6% of cases. The 73.3% of patients underwent bilateral CSD and the mean effective surgical time was 10.8 ± 2.4 min per side; no major periprocedural complication occurred. After a median follow-up time of 15 months (IQR: 8.5-24.5 months), the primary outcome occurred in 47.6% of cases. All patients experienced a reduction of ICD shocks after CSD (3.1 ICD shocks/patient before vs. 0.3 ICD shocks/patient after CSD; p-value: 0.001). Bilateral CSD and a VT cycle length < 340 ms were associated with better outcomes.

conclusionsA modified CSD approach with stellate ganglion sparing appears to be safe, fast, and effective in the treatment of patients with SHD and refractory VTs.

Indexed as

SympathectomyTachycardia, VentricularAgedDefibrillators, ImplantableFemaleHumansMaleMiddle AgedRetrospective StudiesTreatment OutcomeCardiac neuromodulationCardiac sympathetic denervationRefractory ventricular arrhythmiasStellate ganglionSympathicotomyVentricular tachycardia

Identifiers

PMID38040851
OpenAlexW4389234720

What OpenQuestion holds

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Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.