ReviewNature reviews. Neuroscience2024
Sleep and circadian rhythmicity as entangled processes serving homeostasis.
Review in Nature reviews. Neuroscience, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 67 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
67 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Pooled it
- Associations between sleep quality and assisted reproductive technology outcomes: a meta-analysis.Archives of gynecology and obstetrics · 2026Pooled it
- Self-Reported Chronotype and Diet Quality in Chinese Adolescents: Insights from a Cross-Sectional Study in Xiamen.Nutrients · 2026Article
- Article
- Dissecting the shared genetic architecture and biological mechanisms linking sleep traits and suicide attempts: from variants to genes.Molecular psychiatry · 2026Article
- Article
- Sleep homeostasis impairment across obstructive sleep apnea severity: findings from a population-based cohort study.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2026Article
- Tryptamine from wake-active monoaminergic neurons regulates sleep homeostasis.Nature neuroscience · 2026Article
- Induction of cortical on/off periods in awake mice fulfills sleep functions.Nature neuroscience · 2026Article
- Human data at odds and in confirmation of the two-process model of sleep regulation-a perspective.Npj biological timing and sleep · 2026Review
- Genetic evidence elucidates the mediating role of sex hormone-binding globulin in the causal relationship linking insomnia to carpal tunnel syndrome.Human genomics · 2026Article
- Article
- Timing is everything: Expert opinion on researching epilepsy rhythms by the ILAE Task Force on Chronobiology.Epilepsia · 2026Review
- How We Sleep, How We Move, How Long We Expect to Live: An Integrative Review of Lifestyle Behaviors and Subjective Life Expectancy.Nutrients · 2026Review
- The vicious cycle of circadian disruption and obstructive sleep apnea: implications for cancer risk.Journal of the National Cancer Center · 2026Article
- Sleep and circadian rhythms in cardiovascular resilience: mechanisms, implications, and a Roadmap for research and interventions.Nature reviews. Cardiology · 2026Review
- Sleep Rhythmicity as a Core Domain of Multidimensional Sleep Health Associated with Cognitive Impairment in Older Men.Nature and science of sleep · 2026Article
- Inflammatory Cytokine-Mediated Interactions Between Pain and Insomnia: Mechanisms and Therapeutic Implications.Journal of pain research · 2026Review
- Circadian rhythms in pediatric neurocritical care: interfaces and opportunities.Frontiers in neurology · 2026Review
- Functional Suppression of CLOCK Activity in Ventromedial Hypothalamic Prodynorphin Neurons Alters Locomotor Activity and Rapid Eye Movement Sleep.Neurology international · 2025Article
7 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Sleep is considered essential for the brain and body. A predominant concept is that sleep is regulated by circadian rhythmicity and sleep homeostasis, processes that were posited to be functionally and mechanistically separate. Here we review and re-evaluate this concept and its assumptions using findings from recent human and rodent studies. Alterations in genes that are central to circadian rhythmicity affect not only sleep timing but also putative markers of sleep homeostasis such as electroencephalogram slow-wave activity (SWA). Perturbations of sleep change the rhythmicity in the expression of core clock genes in tissues outside the central clock. The dynamics of recovery from sleep loss vary across sleep variables: SWA and immediate early genes show an early response, but the recovery of non-rapid eye movement and rapid eye movement sleep follows slower time courses. Changes in the expression of many genes in response to sleep perturbations outlast the effects on SWA and time spent asleep. These findings are difficult to reconcile with the notion that circadian- and sleep-wake-driven processes are mutually independent and that the dynamics of sleep homeostasis are reflected in a single variable. Further understanding of how both sleep and circadian rhythmicity contribute to the homeostasis of essential physiological variables may benefit from the assessment of multiple sleep and molecular variables over longer time scales.
Indexed as
Identifiers
38040815What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.