Evidence map›Paper›PMID 38040780›Full record

ArticleScientific reports2023

Exploring relationships among multi-disciplinary assessments for knee joint health in service members with traumatic unilateral lower limb loss: a two-year longitudinal investigation.

Joseph G Wasser, Brad D Hendershot, Julian C Acasio, Lauren D Dodd, Rebecca L Krupenevich, Alison L Pruziner, Ross H Miller, Stephen M Goldman, Michael S Valerio, Lien T Senchak and 5 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.3field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 4 institutions in 1 country.

Joseph G WasserDepartment of Rehabilitation, Walter Reed National Military Medical Center, Bethesda, MD, USA.
Brad D HendershotDepartment of Rehabilitation, Walter Reed National Military Medical Center, Bethesda, MD, USA. bradford.d.hendershot2.civ@health.mil.
Julian C AcasioDepartment of Rehabilitation, Walter Reed National Military Medical Center, Bethesda, MD, USA.
Lauren D DoddDepartment of Rehabilitation, Walter Reed National Military Medical Center, Bethesda, MD, USA.
Rebecca L KrupenevichDepartment of Rehabilitation, Walter Reed National Military Medical Center, Bethesda, MD, USA.
Alison L PruzinerDepartment of Rehabilitation, Walter Reed National Military Medical Center, Bethesda, MD, USA.
Ross H MillerDepartment of Kinesiology, University of Maryland, College Park, MD, USA.
Stephen M GoldmanResearch and Surveillance Section, Extremity Trauma and Amputation Center of Excellence, Research and Engineering Directorate, Defense Health Agency, Falls Church, VA, USA.
Michael S ValerioResearch and Surveillance Section, Extremity Trauma and Amputation Center of Excellence, Research and Engineering Directorate, Defense Health Agency, Falls Church, VA, USA.
Lien T SenchakDepartment of Diagnostic Radiology, Walter Reed National Military Medical Center, Bethesda, MD, USA.
Mark D MurpheyDepartment of Diagnostic Radiology, Walter Reed National Military Medical Center, Bethesda, MD, USA.
David A HeltzelDepartment of Diagnostic Radiology, Walter Reed National Military Medical Center, Bethesda, MD, USA.
Michael G FazioDepartment of Diagnostic Radiology, Walter Reed National Military Medical Center, Bethesda, MD, USA.
Christopher L DearthDepartment of Rehabilitation, Walter Reed National Military Medical Center, Bethesda, MD, USA.
Nelson A HagerDepartment of Physical Medicine and Rehabilitation, Uniformed Services University of the Health Sciences, Bethesda, MD, USA.
Walter Reed National Military Medical Center · USUniformed Services University of the Health Sciences · USDefense Health Agency · USUniversity of Maryland, College Park · US

Funding

Center for Rehabilitation Sciences Research HU0001-11-1-0004 and HU0001-15-2-0003Extremity Trauma and Amputation Center of Excellence HU0001-20-2-0038
6 · The paper itself

Abstract

Motivated by the complex and multifactorial etiologies of osteoarthritis, here we use a comprehensive approach evaluating knee joint health after unilateral lower limb loss. Thirty-eight male Service members with traumatic, unilateral lower limb loss (mean age = 38 yr) participated in a prospective, two-year longitudinal study comprehensively evaluating contralateral knee joint health (i.e., clinical imaging, gait biomechanics, physiological biomarkers, and patient-reported outcomes); seventeen subsequently returned for a two-year follow-up visit. For this subset with baseline and follow-up data, outcomes were compared between timepoints, and associations evaluated between values at baseline with two-year changes in tri-compartmental joint space. Upon follow-up, knee joint health worsened, particularly among seven Service members who presented at baseline with no joint degeneration (KL = 0) but returned with evidence of degeneration (KL ≥ 1). Joint space narrowing was associated with greater patellar tilt (r[12] = 0.71, p = 0.01), external knee adduction moment (r[13] = 0.64, p = 0.02), knee adduction moment impulse (r[13] = 0.61, p = 0.03), and CTX-1 concentration (r[11] = 0.83, p = 0.001), as well as lesser KOOS

Indexed as

Knee JointOsteoarthritis, KneeAdultBiomechanical PhenomenaGaitHumansLongitudinal StudiesLower ExtremityMaleProspective Studies

Identifiers

PMID38040780
PMCPMC10692131
OpenAlexW4389238737

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.